DegronMD

Uniprot ID: Q2TAM9

Source protein: Tumor suppressor candidate gene 1 protein

Source gene: TUSC1

Class: LIG_APCC_ABBA_1

Location: 173:178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7334

ASA_SCORE: 96.0167

COIL: 0.2208

CONS_SCORE: 0.9879

DSS_SCORE: 0.572

HELIX: 0.7842

FCONS_SCORE: 1.1381

RIG_SCORE: 0.7432

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E178K	TCGA-J1-A4AH	LUSC	TCGA	LQLHLE	LIG_APCC_ABBA_1	0.7022
p.E178K	DO45479	LUSC	ICGC	LQLHLE	LIG_APCC_ABBA_1	0.7022
p.E178Q	TCGA-JW-A5VL	CESC	TCGA	LQLHLE	LIG_APCC_ABBA_1	0.6744
p.E178Q	DO49976	CESC	ICGC	LQLHLE	LIG_APCC_ABBA_1	0.6744
p.R170Q	ACH-000958	Colon/Colorectal Cancer	CCLE	LQLHLE	LIG_APCC_ABBA_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAM9	Tumor suppressor candidate gene 1 protein	LIG_APCC_ABBA_1	173:178	LQLHLE	APC,CDC20,FZR1	0.7334	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons