DegronMD

Uniprot ID: Q9Y6N6

Source protein: Laminin subunit gamma-3

Source gene: LAMC3

Class: SCF_FBXL2

Location: 908:915

E3 ligase: FBXL2

DEGRON score: 0.6208

ASA_SCORE: 77.625

COIL: 0.8239

CONS_SCORE: 0.7659

DSS_SCORE: 0.0071

HELIX: 0.0188

FCONS_SCORE: 1.0009

RIG_SCORE: 0.7252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P903L	TCGA-56-7730	LUSC	TCGA	LQPGRGCR	SCF_FBXL2	0.1944
p.P903L	DO26617	LUSC	ICGC	LQPGRGCR	SCF_FBXL2	0.1944
p.R900H	TCGA-A5-A0G1	UCEC	TCGA	LQPGRGCR	SCF_FBXL2	0.1111
p.R900H	DO42472	UCEC	ICGC	LQPGRGCR	SCF_FBXL2	0.1111
p.R915W	TCGA-AA-3672	COAD	TCGA	LQPGRGCR	SCF_FBXL2	0.8634
p.R915W	DO9010	COAD	ICGC	LQPGRGCR	SCF_FBXL2	0.8634
p.G913S	TCGA-EE-A29T	SKCM	TCGA	LQPGRGCR	SCF_FBXL2	0.6993
p.G913S	DO37742	SKCM	ICGC	LQPGRGCR	SCF_FBXL2	0.6993
p.P903H	TCGA-FS-A1ZZ	SKCM	TCGA	LQPGRGCR	SCF_FBXL2	0.1944
p.P903H	DO37412	SKCM	ICGC	LQPGRGCR	SCF_FBXL2	0.1944
p.P921Q	DO224914	BRCA	ICGC	LQPGRGCR	SCF_FBXL2	0.1667
p.R912T	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LQPGRGCR	SCF_FBXL2	0.7876
p.R912T	ACH-000785	Lung Cancer	CCLE	LQPGRGCR	SCF_FBXL2	0.7876
p.R912T	NCI-H2126	lung	COSMIC	LQPGRGCR	SCF_FBXL2	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6N6	Laminin subunit gamma-3	SCF_FBXL2	908:915	LQPGRGCR	FBXL2	0.6208	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons