DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQPLRGQRR
Uniprot ID:
D6RIA3
Source protein:
Uncharacterized protein C4orf54
Source gene:
C4orf54
Class:
SCF_FBXL2
Location:
114:122
E3 ligase:
FBXL2
DEGRON score:
0.9623
ASA_SCORE:
85.2667
COIL:
0.6867
CONS_SCORE:
0.5685
DSS_SCORE:
0.4492
HELIX:
0.2367
FCONS_SCORE:
1.1373
RIG_SCORE:
0.7404
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with C4orf54 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQPLRGQRR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
D6RIA3
Uncharacterized protein C4orf54
SCF_FBXL2
114:122
LQPLRGQRR
FBXL2
0.9623
More...
