DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQPQRGGPGR
Uniprot ID:
C9J069
Source protein:
Apical junction component 1 homolog
Source gene:
AJM1
Class:
SCF_FBXL2
Location:
151:160
E3 ligase:
FBXL2
DEGRON score:
0.6039
ASA_SCORE:
94.54
COIL:
0.9574
CONS_SCORE:
0.677
DSS_SCORE:
0.492
HELIX:
0.018
FCONS_SCORE:
1.0211
RIG_SCORE:
0.6085
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with AJM1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQPQRGGPGR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
C9J069
Apical junction component 1 homolog
SCF_FBXL2
151:160
LQPQRGGPGR
FBXL2
0.6039
More...
