DegronMD

Uniprot ID: Q8WWR8

Source protein: Sialidase-4

Source gene: NEU4

Class: SCF_FBXL2

Location: 337:345

E3 ligase: FBXL2

DEGRON score: 0.989

ASA_SCORE: 51.1667

COIL: 0.697

CONS_SCORE: 0.3361

DSS_SCORE: 0.8641

HELIX: 0.0361

FCONS_SCORE: 1.0497

RIG_SCORE: 0.5616

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P330L	TCGA-05-4382	LUAD	TCGA	LQPRGDGPR	SCF_FBXL2	0.1389
p.P330L	DO24900	LUAD	ICGC	LQPRGDGPR	SCF_FBXL2	0.1389
p.P343H	TCGA-05-4420	LUAD	TCGA	LQPRGDGPR	SCF_FBXL2	0.7694
p.P343S	TCGA-56-7731	LUSC	TCGA	LQPRGDGPR	SCF_FBXL2	0.6752
p.Q351K	TCGA-99-8028	LUAD	TCGA	LQPRGDGPR	SCF_FBXL2	0.1667
p.Q351K	DO23561	LUAD	ICGC	LQPRGDGPR	SCF_FBXL2	0.1667
p.E328K	TCGA-EB-A44O	SKCM	TCGA	LQPRGDGPR	SCF_FBXL2	0.0833
p.E328K	DO47272	SKCM	ICGC	LQPRGDGPR	SCF_FBXL2	0.0833
p.V329G	DO48382	BLCA	ICGC	LQPRGDGPR	SCF_FBXL2	0.1111
p.R336H	DO234392	ESAD	ICGC	LQPRGDGPR	SCF_FBXL2	0.3056
p.R336H	DO234417	ESAD	ICGC	LQPRGDGPR	SCF_FBXL2	0.3056
p.V334A	DO233207	GACA	ICGC	LQPRGDGPR	SCF_FBXL2	0.25
p.P330H	DO24675	LUAD	ICGC	LQPRGDGPR	SCF_FBXL2	0.1389
p.P342S	DO45527	LUSC	ICGC	LQPRGDGPR	SCF_FBXL2	0.6752
p.R340W	DO227570	PACA	ICGC	LQPRGDGPR	SCF_FBXL2	0.8634
p.G355R	DO48665	SKCM	ICGC	LQPRGDGPR	SCF_FBXL2	0.0556
p.G341W	DO229218	THCA	ICGC	LQPRGDGPR	SCF_FBXL2	0.7825
p.A334V	SIDM01203	Other Solid Cancers	GDSC	LQPRGDGPR	SCF_FBXL2	0.25
p.A334V	NTERA-2_cl_D1	testis	COSMIC	LQPRGDGPR	SCF_FBXL2	0.25
p.R353Q	SIDM00014	Colorectal Carcinoma	GDSC	LQPRGDGPR	SCF_FBXL2	0.1111
p.R353Q	LIM1215	large_intestine	COSMIC	LQPRGDGPR	SCF_FBXL2	0.1111
p.H327L	SIDM00622	Glioblastoma	GDSC	LQPRGDGPR	SCF_FBXL2	0.0556
p.H327L	D-247MG	central_nervous_system	COSMIC	LQPRGDGPR	SCF_FBXL2	0.0556
p.G352V	ACH-000979	Prostate Cancer	CCLE	LQPRGDGPR	SCF_FBXL2	0.1389
p.G352V	DU-145	prostate	COSMIC	LQPRGDGPR	SCF_FBXL2	0.1389
p.P344T	ACH-001680	Lymphoma	CCLE	LQPRGDGPR	SCF_FBXL2	0.5919
p.P344T	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LQPRGDGPR	SCF_FBXL2	0.5919
p.R340Q	LIM1215	large_intestine	COSMIC	LQPRGDGPR	SCF_FBXL2	0.7329
p.R352Q	LIM1215	large_intestine	COSMIC	LQPRGDGPR	SCF_FBXL2	0.1389
p.A333V	NTERA-2_cl_D1	testis	COSMIC	LQPRGDGPR	SCF_FBXL2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQPRGDGPR

Degron related mutations and impact score

Drug responses associated with NEU4 mutations

All proteins holding degron of LQPRGDGPR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWR8	Sialidase-4	SCF_FBXL2	337:345	LQPRGDGPR	FBXL2	0.989	More...