DegronMD - Q8WWR8(NEU4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P330L	TCGA-05-4382	LUAD	TCGA	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1389
p.P330L	DO24900	LUAD	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1389
p.P343H	TCGA-05-4420	LUAD	TCGA	LQPRGDGPR	SCF_FBXL2	337:345	Mutation altering degron motif	0.7694
p.R22Q	TCGA-19-5959	GBM	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation altering degron motif	0.7329
p.P343S	TCGA-56-7731	LUSC	TCGA	LQPRGDGPR	SCF_FBXL2	337:345	Mutation altering degron motif	0.6752
p.Q351K	TCGA-99-8028	LUAD	TCGA	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1667
p.Q351K	DO23561	LUAD	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1667
p.P20T	TCGA-CV-7238	HNSC	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation altering degron motif	0.7031
p.G15V	TCGA-D3-A2J9	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.G15V	TCGA-D3-A2J9	SKCM	TCGA	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1944
p.G15V	DO38141	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.G15V	DO38141	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1944
p.E27K	TCGA-D3-A5GN	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation altering degron motif	0.7022
p.E27K	DO47317	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation altering degron motif	0.7022
p.R18C	TCGA-E7-A7XN	BLCA	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation altering degron motif	0.8301
p.R18C	TCGA-EJ-7782	PRAD	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation altering degron motif	0.8301
p.E328K	TCGA-EB-A44O	SKCM	TCGA	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.0833
p.E328K	DO47272	SKCM	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.0833
p.R9K	TCGA-EE-A29E	SKCM	TCGA	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.6126
p.R9K	DO37831	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.6126
p.R30M	TCGA-EE-A2GI	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.R30M	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.R30M	NCI-H2342	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.L25F	TCGA-EE-A2GN	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation altering degron motif	0.6981
p.E29K	TCGA-EE-A2MM	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.R28Q	TCGA-ER-A198	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R28Q	DO47563	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R28W	TCGA-F5-6814	READ	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R28L	TCGA-FS-A1Z0	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.P8T	TCGA-FS-A1Z4	SKCM	TCGA	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.7031
p.P8T	DO37462	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.7031
p.R30S	TCGA-IB-7651	PAAD	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.V37M	TCGA-MP-A4T8	LUAD	TCGA	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.0556
p.V37M	DO45348	LUAD	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.0556
p.V37M	DO229076	PRAD	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.0556
p.V37M	SIDM02015	Colorectal Carcinoma	GDSC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.0556
p.V329G	DO48382	BLCA	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1111
p.R17C	DO51878	BLCA	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R17C	DO51878	BLCA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1389
p.R17C	DO229389	BTCA	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R17C	DO229389	BTCA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1389
p.R17C	DO36256	PRAD	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R17C	DO36256	PRAD	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1389
p.R336H	DO234392	ESAD	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.3056
p.R336H	DO234417	ESAD	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.3056
p.V334A	DO233207	GACA	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.25
p.R21Q	DO11651	GBM	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation altering degron motif	0.7329
p.P7T	DO15246	HNSC	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.7031
p.T35S	DO24692	LUAD	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.1111
p.P330H	DO24675	LUAD	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1389
p.P342S	DO45527	LUSC	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation altering degron motif	0.6752
p.P7S	DO220899	MELA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.6752
p.E16K	DO222678	MELA	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.E16K	DO222678	MELA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1667
p.E16K	DO37770	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.E16K	DO37770	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1667
p.E16D	DO50707	ORCA	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.E16D	DO50707	ORCA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1667
p.R29S	DO46657	PAAD	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.R340W	DO227570	PACA	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation altering degron motif	0.8634
p.R15W	DO36556	READ	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.R15W	DO36556	READ	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1944
p.L12F	DO37896	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.1667
p.L12F	DO37896	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.2778
p.R17M	DO37410	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R17M	DO37410	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1389
p.R17M	NCI-H2342	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R17M	NCI-H2342	lung	COSMIC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1389
p.R15L	DO37431	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.R15L	DO37431	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1944
p.G355R	DO48665	SKCM	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.0556
p.G341W	DO229218	THCA	ICGC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation altering degron motif	0.7825
p.G32D	SIDM01943	Colorectal Carcinoma	GDSC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.1944
p.A334V	SIDM01203	Other Solid Cancers	GDSC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.25
p.A334V	NTERA-2_cl_D1	testis	COSMIC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.25
p.A5S	SIDM00568	Gastric Carcinoma	GDSC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.7588
p.A5S	OCUM-1	stomach	COSMIC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.7588
p.R353Q	SIDM00014	Colorectal Carcinoma	GDSC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1111
p.R353Q	LIM1215	large intestine	COSMIC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1111
p.R30K	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.R30K	NCI-H441	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.H327L	SIDM00622	Glioblastoma	GDSC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.0556
p.H327L	D-247MG	central nervous system	COSMIC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.0556
p.A6T	SIDM01776	Plasma Cell Myeloma	GDSC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation altering degron motif	0.7139
p.R17K	ACH-000638	Lung Cancer	CCLE	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R17K	ACH-000638	Lung Cancer	CCLE	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1389
p.R17K	NCI-H441	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.R17K	NCI-H441	lung	COSMIC	VPRTPSRT	DEG_SCF_FBW7_1	3:10	Mutation rewiring degron network	0.1389
p.G352V	ACH-000979	Prostate Cancer	CCLE	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1389
p.G352V	DU-145	prostate	COSMIC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1389
p.V30M	ACH-000983	Leukemia	CCLE	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.V30M	KCL-22	haematopoietic and lymphoid tissue	COSMIC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.25
p.P29L	ACH-000995	Leukemia	CCLE	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.P29L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.P344T	ACH-001680	Lymphoma	CCLE	LQPRGDGPR	SCF_FBXL2	337:345	Mutation altering degron motif	0.5919
p.P344T	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation altering degron motif	0.5919
p.R29M	NCI-H2342	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.R29K	NCI-H441	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2778
p.R340Q	LIM1215	large intestine	COSMIC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation altering degron motif	0.7329
p.R352Q	LIM1215	large intestine	COSMIC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.1389
p.A333V	NTERA-2_cl_D1	testis	COSMIC	LQPRGDGPR	SCF_FBXL2	337:345	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEU4

UniProt ID: Q8WWR8

Entrez ID: 129807

Protein name: Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEU4 in