DegronMD

Uniprot ID: Q8WWR8

Source protein: Sialidase-4

Source gene: NEU4

Class: DEG_SCF_FBW7_1

Location: 3:10

E3 ligase: FBXW7

DEGRON score: 0.7127

ASA_SCORE: 96.3125

COIL: 0.8231

CONS_SCORE: 0.4699

DSS_SCORE: 0.7002

HELIX: 0.0083

FCONS_SCORE: 0.8239

RIG_SCORE: 0.7201

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G15V	TCGA-D3-A2J9	SKCM	TCGA	VPRTPSRT	DEG_SCF_FBW7_1	0.1944
p.G15V	DO38141	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1944
p.R9K	TCGA-EE-A29E	SKCM	TCGA	VPRTPSRT	DEG_SCF_FBW7_1	0.6126
p.R9K	DO37831	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.6126
p.P8T	TCGA-FS-A1Z4	SKCM	TCGA	VPRTPSRT	DEG_SCF_FBW7_1	0.7031
p.P8T	DO37462	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.7031
p.R17C	DO51878	BLCA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1389
p.R17C	DO229389	BTCA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1389
p.R17C	DO36256	PRAD	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1389
p.P7T	DO15246	HNSC	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.7031
p.P7S	DO220899	MELA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.6752
p.E16K	DO222678	MELA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1667
p.E16K	DO37770	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1667
p.E16D	DO50707	ORCA	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1667
p.R15W	DO36556	READ	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1944
p.L12F	DO37896	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.2778
p.R17M	DO37410	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1389
p.R17M	NCI-H2342	lung	COSMIC	VPRTPSRT	DEG_SCF_FBW7_1	0.1389
p.R15L	DO37431	SKCM	ICGC	VPRTPSRT	DEG_SCF_FBW7_1	0.1944
p.A5S	SIDM00568	Gastric Carcinoma	GDSC	VPRTPSRT	DEG_SCF_FBW7_1	0.7588
p.A5S	OCUM-1	stomach	COSMIC	VPRTPSRT	DEG_SCF_FBW7_1	0.7588
p.A6T	SIDM01776	Plasma Cell Myeloma	GDSC	VPRTPSRT	DEG_SCF_FBW7_1	0.7139
p.R17K	ACH-000638	Lung Cancer	CCLE	VPRTPSRT	DEG_SCF_FBW7_1	0.1389
p.R17K	NCI-H441	lung	COSMIC	VPRTPSRT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWR8	Sialidase-4	DEG_SCF_FBW7_1	3:10	VPRTPSRT	FBXW7	0.7127	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons