DegronMD

Uniprot ID: Q8WWR8

Source protein: Sialidase-4

Source gene: NEU4

Class: DEG_COP1_1

Location: 18:27

E3 ligase: COP1

DEGRON score: 0.879

ASA_SCORE: 23.31

COIL: 0.2468

CONS_SCORE: 0.6768

DSS_SCORE: 0.3883

HELIX: 0.0047

FCONS_SCORE: 1.23

RIG_SCORE: 0.7772

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R22Q	TCGA-19-5959	GBM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.7329
p.P20T	TCGA-CV-7238	HNSC	TCGA	TGLTYRVPSL	DEG_COP1_1	0.7031
p.G15V	TCGA-D3-A2J9	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.25
p.G15V	DO38141	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.25
p.E27K	TCGA-D3-A5GN	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.7022
p.E27K	DO47317	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.7022
p.R18C	TCGA-E7-A7XN	BLCA	TCGA	TGLTYRVPSL	DEG_COP1_1	0.8301
p.R18C	TCGA-EJ-7782	PRAD	TCGA	TGLTYRVPSL	DEG_COP1_1	0.8301
p.R30M	TCGA-EE-A2GI	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.25
p.R30M	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	TGLTYRVPSL	DEG_COP1_1	0.25
p.R30M	NCI-H2342	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.25
p.L25F	TCGA-EE-A2GN	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.6981
p.E29K	TCGA-EE-A2MM	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.2778
p.R28Q	TCGA-ER-A198	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R28Q	DO47563	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R28W	TCGA-F5-6814	READ	TCGA	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R28L	TCGA-FS-A1Z0	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R30S	TCGA-IB-7651	PAAD	TCGA	TGLTYRVPSL	DEG_COP1_1	0.25
p.V37M	TCGA-MP-A4T8	LUAD	TCGA	TGLTYRVPSL	DEG_COP1_1	0.0556
p.V37M	DO45348	LUAD	ICGC	TGLTYRVPSL	DEG_COP1_1	0.0556
p.V37M	DO229076	PRAD	ICGC	TGLTYRVPSL	DEG_COP1_1	0.0556
p.V37M	SIDM02015	Colorectal Carcinoma	GDSC	TGLTYRVPSL	DEG_COP1_1	0.0556
p.R17C	DO51878	BLCA	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17C	DO229389	BTCA	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17C	DO36256	PRAD	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R21Q	DO11651	GBM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.7329
p.T35S	DO24692	LUAD	ICGC	TGLTYRVPSL	DEG_COP1_1	0.1111
p.E16K	DO222678	MELA	ICGC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.E16K	DO37770	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.E16D	DO50707	ORCA	ICGC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.R29S	DO46657	PAAD	ICGC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.R15W	DO36556	READ	ICGC	TGLTYRVPSL	DEG_COP1_1	0.25
p.L12F	DO37896	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.1667
p.R17M	DO37410	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17M	NCI-H2342	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R15L	DO37431	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.25
p.G32D	SIDM01943	Colorectal Carcinoma	GDSC	TGLTYRVPSL	DEG_COP1_1	0.1944
p.R30K	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	TGLTYRVPSL	DEG_COP1_1	0.25
p.R30K	NCI-H441	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.25
p.R17K	ACH-000638	Lung Cancer	CCLE	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17K	NCI-H441	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.V30M	ACH-000983	Leukemia	CCLE	TGLTYRVPSL	DEG_COP1_1	0.25
p.V30M	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.25
p.P29L	ACH-000995	Leukemia	CCLE	TGLTYRVPSL	DEG_COP1_1	0.2778
p.P29L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.R29M	NCI-H2342	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.R29K	NCI-H441	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TGLTYRVPSL

Degron related mutations and impact score

Drug responses associated with NEU4 mutations

All proteins holding degron of TGLTYRVPSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWR8	Sialidase-4	DEG_COP1_1	18:27	TGLTYRVPSL	COP1	0.879	More...