DegronMD

Uniprot ID: Q8WWR8

Source protein: Sialidase-4

Source gene: NEU4

Class: DEG_COP1_1

Location: 18:27

E3 ligase: COP1

DEGRON score: 0.879

ASA_SCORE: 23.31

COIL: 0.2468

CONS_SCORE: 0.6768

DSS_SCORE: 0.3883

HELIX: 0.0047

FCONS_SCORE: 1.23

RIG_SCORE: 0.7772

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R18C	TCGA-E7-A7XN	BLCA	TCGA	TGLTYRVPSL	DEG_COP1_1	0.8301
p.R18C	TCGA-EJ-7782	PRAD	TCGA	TGLTYRVPSL	DEG_COP1_1	0.8301
p.R22Q	TCGA-19-5959	GBM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.7329
p.R21Q	DO11651	GBM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.7329
p.P20T	TCGA-CV-7238	HNSC	TCGA	TGLTYRVPSL	DEG_COP1_1	0.7031
p.E27K	TCGA-D3-A5GN	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.7022
p.E27K	DO47317	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.7022
p.L25F	TCGA-EE-A2GN	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.6981
p.R28Q	TCGA-ER-A198	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R28Q	DO47563	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R28W	TCGA-F5-6814	READ	TCGA	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R28L	TCGA-FS-A1Z0	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17C	DO51878	BLCA	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17C	DO229389	BTCA	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17C	DO36256	PRAD	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17M	DO37410	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17M	NCI-H2342	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17K	ACH-000638	Lung Cancer	CCLE	TGLTYRVPSL	DEG_COP1_1	0.3056
p.R17K	NCI-H441	lung	COSMIC	TGLTYRVPSL	DEG_COP1_1	0.3056
p.E29K	TCGA-EE-A2MM	SKCM	TCGA	TGLTYRVPSL	DEG_COP1_1	0.2778
p.E16K	DO222678	MELA	ICGC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.E16K	DO37770	SKCM	ICGC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.E16D	DO50707	ORCA	ICGC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.R29S	DO46657	PAAD	ICGC	TGLTYRVPSL	DEG_COP1_1	0.2778
p.P29L	ACH-000995	Leukemia	CCLE	TGLTYRVPSL	DEG_COP1_1	0.2778

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWR8	Sialidase-4	DEG_COP1_1	18:27	TGLTYRVPSL	COP1	0.879	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons