DegronMD

Uniprot ID: P03971

Source protein: Muellerian-inhibiting factor

Source gene: AMH

Class: SCF_FBXL2

Location: 216:224

E3 ligase: FBXL2

DEGRON score: 0.7087

ASA_SCORE: 77.2

COIL: 0.5678

CONS_SCORE: 0.3345

DSS_SCORE: 0.3428

HELIX: 0.0381

FCONS_SCORE: 0.768

RIG_SCORE: 0.7357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S226R	TCGA-3A-A9IS	PAAD	TCGA	LQPRGEDSR	SCF_FBXL2	0.2778
p.S226R	DO51682	PAAD	ICGC	LQPRGEDSR	SCF_FBXL2	0.2778
p.S210F	DO6144	BRCA	ICGC	LQPRGEDSR	SCF_FBXL2	0.1667
p.R229W	DO233760	GACA	ICGC	LQPRGEDSR	SCF_FBXL2	0.1944
p.Q217R	DO233941	GACA	ICGC	LQPRGEDSR	SCF_FBXL2	0.7329
p.S226I	DO228952	LICA	ICGC	LQPRGEDSR	SCF_FBXL2	0.2778
p.E221K	DO37418	SKCM	ICGC	LQPRGEDSR	SCF_FBXL2	0.591
p.R229Q	SIDM01313	Colorectal Carcinoma	GDSC	LQPRGEDSR	SCF_FBXL2	0.1944
p.A232S	ACH-000817	Myeloma	CCLE	LQPRGEDSR	SCF_FBXL2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P03971	Muellerian-inhibiting factor	SCF_FBXL2	216:224	LQPRGEDSR	FBXL2	0.7087	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons