DegronMD

Uniprot ID: A7KAX9

Source protein: Rho GTPase-activating protein 32

Source gene: ARHGAP32

Class: LIG_APCC_ABBA_1

Location: 1637:1642

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9913

ASA_SCORE: 93.6

COIL: 0.8083

CONS_SCORE: 0.3799

DSS_SCORE: 0.3579

HELIX: 0.0728

FCONS_SCORE: 0.9902

RIG_SCORE: 0.794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1645Q	TCGA-CK-5913	COAD	TCGA	LQPYFE	LIG_APCC_ABBA_1	0.25
p.R1629S	TCGA-ER-A2NG	SKCM	TCGA	LQPYFE	LIG_APCC_ABBA_1	0.1111
p.R1645W	TCGA-HU-A4GP	STAD	TCGA	LQPYFE	LIG_APCC_ABBA_1	0.25
p.E1635D	DO225278	BRCA	ICGC	LQPYFE	LIG_APCC_ABBA_1	0.7222
p.H1638R	DO45005	LIHC	ICGC	LQPYFE	LIG_APCC_ABBA_1	0.8244
p.D1651N	DO26444	LUSC	ICGC	LQPYFE	LIG_APCC_ABBA_1	0.0833
p.V1648M	DO50078	UCEC	ICGC	LQPYFE	LIG_APCC_ABBA_1	0.1667
p.G1644V	SIDM01156	Small Cell Lung Carcinoma	GDSC	LQPYFE	LIG_APCC_ABBA_1	0.2778
p.G1644V	SW1271	lung	COSMIC	LQPYFE	LIG_APCC_ABBA_1	0.2778
p.R1650S	ACH-001061	Colon/Colorectal Cancer	CCLE	LQPYFE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	LIG_APCC_ABBA_1	1637:1642	LQPYFE	APC,CDC20,FZR1	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons