DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LQTPIVT
Uniprot ID:
Q8N3J3
Source protein:
Homologous recombination OB-fold protein
Source gene:
HROB
Class:
DEG_SCF_FBW7_1
Location:
363:369
E3 ligase:
FBXW7
DEGRON score:
0.8573
ASA_SCORE:
85.8143
COIL:
0.7227
CONS_SCORE:
0.3689
DSS_SCORE:
0.5482
HELIX:
0.0616
FCONS_SCORE:
1.1159
RIG_SCORE:
0.7448
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HROB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQTPIVT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N3J3
Homologous recombination OB-fold protein
DEG_SCF_FBW7_1
363:369
LQTPIVT
FBXW7
0.8573
More...