DegronMD

Uniprot ID: O43493

Source protein: Trans-Golgi network integral membrane protein 2

Source gene: TGOLN2

Class: DEG_SCF_FBW7_1

Location: 130:136

E3 ligase: FBXW7

DEGRON score: 0.9795

ASA_SCORE: 111.2286

COIL: 0.9613

CONS_SCORE: 0.683

DSS_SCORE: 0.8148

HELIX: 0.0227

FCONS_SCORE: 0.9665

RIG_SCORE: 0.5873

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T137I	TCGA-64-1681	LUAD	TCGA	LQTPKDS	DEG_SCF_FBW7_1	0.3056
p.T137I	DO23899	LUAD	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.3056
p.A142V	TCGA-EO-A22R	UCEC	TCGA	LQTPKDS	DEG_SCF_FBW7_1	0.1667
p.A142V	DO42713	UCEC	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.1667
p.P128L	TCGA-EQ-A4SO	STAD	TCGA	LQTPKDS	DEG_SCF_FBW7_1	0.2778
p.P128L	DO47893	STAD	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.2778
p.K134T	TCGA-EY-A1GI	UCEC	TCGA	LQTPKDS	DEG_SCF_FBW7_1	0.6195
p.K134T	DO41211	UCEC	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.6195
p.A144V	TCGA-G4-6588	COAD	TCGA	LQTPKDS	DEG_SCF_FBW7_1	0.1111
p.A144V	DO10140	COAD	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.1111
p.S140P	TCGA-HD-7832	HNSC	TCGA	LQTPKDS	DEG_SCF_FBW7_1	0.2222
p.S140P	DO16061	HNSC	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.2222
p.T123S	TCGA-LG-A9QC	LIHC	TCGA	LQTPKDS	DEG_SCF_FBW7_1	0.1389
p.T123S	DO49701	LIHC	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.1389
p.Q131E	TCGA-LL-A5YO	BRCA	TCGA	LQTPKDS	DEG_SCF_FBW7_1	0.5633
p.Q131E	DO50050	BRCA	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.5633
p.D135E	DO229009	LICA	ICGC	LQTPKDS	DEG_SCF_FBW7_1	0.5647
p.G141D	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00524	Small Cell Lung Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00662	Melanoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM01021	Glioblastoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00820	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00941	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00819	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00112	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM01066	Melanoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00438	B-Lymphoblastic Leukemia	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00920	Breast Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00479	Esophageal Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM01012	Other Blood Cancers	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00124	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00056	Thyroid Gland Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM00861	Ovarian Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944
p.G141D	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQTPKDS

Degron related mutations and impact score

Drug responses associated with TGOLN2 mutations

All proteins holding degron of LQTPKDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43493	Trans-Golgi network integral membrane protein 2	DEG_SCF_FBW7_1	130:136	LQTPKDS	FBXW7	0.9795	More...