DegronMD - O43493(TGOLN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T137I	TCGA-64-1681	LUAD	TCGA	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.3056
p.T137I	DO23899	LUAD	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.3056
p.K89N	TCGA-AX-A2HC	UCEC	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation substituting flanking lysine	0.3056
p.K89N	TCGA-AX-A2HC	UCEC	TCGA	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation substituting flanking lysine	0.2778
p.K89N	DO41572	UCEC	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation substituting flanking lysine	0.3056
p.K89N	DO41572	UCEC	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation substituting flanking lysine	0.2778
p.S71C	TCGA-AZ-5407	COAD	TCGA	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation blocking phosphorylation signal	0.6389
p.S71C	TCGA-AZ-5407	COAD	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.6111
p.S71C	TCGA-AZ-5407	COAD	TCGA	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation blocking phosphorylation signal	0.6389
p.S71C	DO8432	COAD	ICGC	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation blocking phosphorylation signal	0.6389
p.S71C	DO8432	COAD	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.6111
p.S71C	DO8432	COAD	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation blocking phosphorylation signal	0.6389
p.S68N	TCGA-B5-A1MX	UCEC	TCGA	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation blocking phosphorylation signal	0.7222
p.S68N	TCGA-B5-A1MX	UCEC	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.5278
p.S68N	TCGA-B5-A1MX	UCEC	TCGA	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation blocking phosphorylation signal	0.5556
p.S68N	DO41999	UCEC	ICGC	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation blocking phosphorylation signal	0.7222
p.S68N	DO41999	UCEC	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.5278
p.S68N	DO41999	UCEC	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation blocking phosphorylation signal	0.5556
p.D79N	TCGA-CV-7242	HNSC	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.5821
p.D79N	TCGA-CV-7242	HNSC	TCGA	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.5821
p.D79N	DO14974	HNSC	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.5821
p.D79N	DO14974	HNSC	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.5821
p.S84L	TCGA-D3-A3C7	SKCM	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.8778
p.S84L	DO47569	SKCM	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.8778
p.A142V	TCGA-EO-A22R	UCEC	TCGA	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1667
p.A142V	DO42713	UCEC	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1667
p.P128L	TCGA-EQ-A4SO	STAD	TCGA	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.2778
p.P128L	DO47893	STAD	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.2778
p.K134T	TCGA-EY-A1GI	UCEC	TCGA	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation altering degron motif	0.6195
p.K134T	DO41211	UCEC	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation altering degron motif	0.6195
p.A144V	TCGA-G4-6588	COAD	TCGA	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1111
p.A144V	DO10140	COAD	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1111
p.S140P	TCGA-HD-7832	HNSC	TCGA	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.2222
p.S140P	DO16061	HNSC	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.2222
p.T123S	TCGA-LG-A9QC	LIHC	TCGA	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1389
p.T123S	DO49701	LIHC	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1389
p.Q131E	TCGA-LL-A5YO	BRCA	TCGA	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation altering degron motif	0.5633
p.Q131E	DO50050	BRCA	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation altering degron motif	0.5633
p.S53A	DO222427	BTCA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation rewiring degron network	0.1389
p.K83R	DO227432	EOPC	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.6126
p.K83R	DO227432	EOPC	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.7237
p.K83R	DO228924	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.6126
p.K83R	DO228924	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.7237
p.K83R	DO228941	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.6126
p.K83R	DO228941	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.7237
p.K83R	DO228899	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.6126
p.K83R	DO228899	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.7237
p.S70W	DO222771	ESCA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation blocking phosphorylation signal	0.6667
p.S70W	DO222771	ESCA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.5833
p.S70W	DO222771	ESCA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation blocking phosphorylation signal	0.6111
p.S70W	ACH-001413	Bladder Cancer	CCLE	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation blocking phosphorylation signal	0.6667
p.S70W	ACH-001413	Bladder Cancer	CCLE	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.5833
p.S70W	ACH-001413	Bladder Cancer	CCLE	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation blocking phosphorylation signal	0.6111
p.T80S	DO228922	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.8227
p.T80S	DO228922	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.8227
p.T80S	DO228933	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.8227
p.T80S	DO228933	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.8227
p.T80S	DO228936	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.8227
p.T80S	DO228936	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.8227
p.T80S	DO228940	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.8227
p.T80S	DO228940	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.8227
p.P60Q	DO228976	LICA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation altering degron motif	0.7035
p.P67T	DO228986	LICA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation rewiring degron network	0.3056
p.P67T	DO228986	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation rewiring degron network	0.0556
p.P67T	DO228986	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation rewiring degron network	0.0833
p.N82K	DO229018	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.5806
p.N82K	DO229018	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.5806
p.S68R	DO229031	LICA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation blocking phosphorylation signal	0.7222
p.S68R	DO229031	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.5278
p.S68R	DO229031	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation blocking phosphorylation signal	0.5556
p.D135E	DO229009	LICA	ICGC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation altering degron motif	0.5647
p.G141D	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00524	Small Cell Lung Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00662	Melanoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM01021	Glioblastoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00820	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00941	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00819	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00112	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM01066	Melanoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00438	B-Lymphoblastic Leukemia	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00920	Breast Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00479	Esophageal Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM01012	Other Blood Cancers	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00124	Kidney Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00056	Thyroid Gland Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM00861	Ovarian Carcinoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.G141D	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPKDS	DEG_SCF_FBW7_1	130:136	Mutation rewiring degron network	0.1944
p.S94T	SIDM00262	Ewing's Sarcoma	GDSC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.5
p.S94T	ES6	bone	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation blocking phosphorylation signal	0.5
p.D93G	SIDM00262	Ewing's Sarcoma	GDSC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation rewiring degron network	0.0833
p.D93G	SIDM00262	Ewing's Sarcoma	GDSC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation rewiring degron network	0.0556
p.D93G	ES6	bone	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation rewiring degron network	0.0833
p.D93G	ES6	bone	COSMIC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation rewiring degron network	0.0556
p.N82H	SIDM01051	Ovarian Carcinoma	GDSC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.6312
p.N82H	SIDM01051	Ovarian Carcinoma	GDSC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.6312
p.N82H	ACH-000936	Ovarian Cancer	CCLE	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.6312
p.N82H	ACH-000936	Ovarian Cancer	CCLE	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.6312
p.N82H	EFO-27	ovary	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation altering degron motif	0.6312
p.N82H	EFO-27	ovary	COSMIC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation altering degron motif	0.6312
p.S66N	SIDM01617	Endometrial Carcinoma	GDSC	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation altering degron motif	0.818
p.S66N	ACH-000994	Endometrial/Uterine Cancer	CCLE	PQTPKDS	DEG_SCF_FBW7_1	60:66	Mutation altering degron motif	0.818
p.K92E	ES6	bone	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation substituting flanking lysine	0.2222
p.K92E	ES6	bone	COSMIC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation substituting flanking lysine	0.1944
p.Q91P	ES6	bone	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	77:84	Mutation rewiring degron network	0.1389
p.Q91P	ES6	bone	COSMIC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	76:83	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TGOLN2

UniProt ID: O43493

Entrez ID: 10618

Protein name: Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TGOLN2 in