DegronMD

Uniprot ID: O43493

Source protein: Trans-Golgi network integral membrane protein 2

Source gene: TGOLN2

Class: DEG_SCF_FBW7_1

Location: 77:84

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 106.5875

COIL: 0.9578

CONS_SCORE: 0.7365

DSS_SCORE: 0.8036

HELIX: 0.0309

FCONS_SCORE: 1.0278

RIG_SCORE: 0.5543

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K89N	TCGA-AX-A2HC	UCEC	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	0.3056
p.K89N	DO41572	UCEC	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.3056
p.S71C	TCGA-AZ-5407	COAD	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	0.6111
p.S71C	DO8432	COAD	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.6111
p.S68N	TCGA-B5-A1MX	UCEC	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	0.5278
p.S68N	DO41999	UCEC	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.5278
p.D79N	TCGA-CV-7242	HNSC	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	0.5821
p.D79N	DO14974	HNSC	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.5821
p.S84L	TCGA-D3-A3C7	SKCM	TCGA	PEDTPNKS	DEG_SCF_FBW7_1	0.8778
p.S84L	DO47569	SKCM	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.8778
p.K83R	DO227432	EOPC	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.6126
p.K83R	DO228924	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.6126
p.K83R	DO228941	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.6126
p.K83R	DO228899	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.6126
p.S70W	DO222771	ESCA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.5833
p.S70W	ACH-001413	Bladder Cancer	CCLE	PEDTPNKS	DEG_SCF_FBW7_1	0.5833
p.T80S	DO228922	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.8227
p.T80S	DO228933	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.8227
p.T80S	DO228936	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.8227
p.T80S	DO228940	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.8227
p.P67T	DO228986	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.0556
p.N82K	DO229018	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.5806
p.S68R	DO229031	LICA	ICGC	PEDTPNKS	DEG_SCF_FBW7_1	0.5278
p.S94T	SIDM00262	Ewing's Sarcoma	GDSC	PEDTPNKS	DEG_SCF_FBW7_1	0.5
p.S94T	ES6	bone	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	0.5
p.D93G	SIDM00262	Ewing's Sarcoma	GDSC	PEDTPNKS	DEG_SCF_FBW7_1	0.0833
p.D93G	ES6	bone	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	0.0833
p.N82H	SIDM01051	Ovarian Carcinoma	GDSC	PEDTPNKS	DEG_SCF_FBW7_1	0.6312
p.N82H	ACH-000936	Ovarian Cancer	CCLE	PEDTPNKS	DEG_SCF_FBW7_1	0.6312
p.N82H	EFO-27	ovary	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	0.6312
p.K92E	ES6	bone	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	0.2222
p.Q91P	ES6	bone	COSMIC	PEDTPNKS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEDTPNKS

Degron related mutations and impact score

Drug responses associated with TGOLN2 mutations

All proteins holding degron of PEDTPNKS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43493	Trans-Golgi network integral membrane protein 2	DEG_SCF_FBW7_1	77:84	PEDTPNKS	FBXW7	0.9929	More...