DegronMD

Uniprot ID: O43493

Source protein: Trans-Golgi network integral membrane protein 2

Source gene: TGOLN2

Class: DEG_SCF_FBW7_1

Location: 60:66

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 112.9

COIL: 0.9739

CONS_SCORE: 0.7286

DSS_SCORE: 0.8774

HELIX: 0.0133

FCONS_SCORE: 1.0205

RIG_SCORE: 0.5009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S71C	TCGA-AZ-5407	COAD	TCGA	PQTPKDS	DEG_SCF_FBW7_1	0.6389
p.S71C	DO8432	COAD	ICGC	PQTPKDS	DEG_SCF_FBW7_1	0.6389
p.S68N	TCGA-B5-A1MX	UCEC	TCGA	PQTPKDS	DEG_SCF_FBW7_1	0.7222
p.S68N	DO41999	UCEC	ICGC	PQTPKDS	DEG_SCF_FBW7_1	0.7222
p.S53A	DO222427	BTCA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	0.1389
p.S70W	DO222771	ESCA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	0.6667
p.S70W	ACH-001413	Bladder Cancer	CCLE	PQTPKDS	DEG_SCF_FBW7_1	0.6667
p.P60Q	DO228976	LICA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	0.7035
p.P67T	DO228986	LICA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	0.3056
p.S68R	DO229031	LICA	ICGC	PQTPKDS	DEG_SCF_FBW7_1	0.7222
p.S66N	SIDM01617	Endometrial Carcinoma	GDSC	PQTPKDS	DEG_SCF_FBW7_1	0.818
p.S66N	ACH-000994	Endometrial/Uterine Cancer	CCLE	PQTPKDS	DEG_SCF_FBW7_1	0.818

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43493	Trans-Golgi network integral membrane protein 2	DEG_SCF_FBW7_1	60:66	PQTPKDS	FBXW7	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons