DegronMD

Uniprot ID: O43493

Source protein: Trans-Golgi network integral membrane protein 2

Source gene: TGOLN2

Class: DEG_SCF_SKP2-CKS1_1

Location: 76:83

E3 ligase: SKP2,CSK1

DEGRON score: 0.9934

ASA_SCORE: 107.5875

COIL: 0.9641

CONS_SCORE: 0.7302

DSS_SCORE: 0.8071

HELIX: 0.0245

FCONS_SCORE: 1.0127

RIG_SCORE: 0.5584

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K89N	TCGA-AX-A2HC	UCEC	TCGA	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K89N	DO41572	UCEC	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.2778
p.S71C	TCGA-AZ-5407	COAD	TCGA	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.6389
p.S71C	DO8432	COAD	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.6389
p.S68N	TCGA-B5-A1MX	UCEC	TCGA	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.5556
p.S68N	DO41999	UCEC	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.5556
p.D79N	TCGA-CV-7242	HNSC	TCGA	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.5821
p.D79N	DO14974	HNSC	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.5821
p.K83R	DO227432	EOPC	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.7237
p.K83R	DO228924	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.7237
p.K83R	DO228941	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.7237
p.K83R	DO228899	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.7237
p.S70W	DO222771	ESCA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S70W	ACH-001413	Bladder Cancer	CCLE	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.T80S	DO228922	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.8227
p.T80S	DO228933	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.8227
p.T80S	DO228936	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.8227
p.T80S	DO228940	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.8227
p.P67T	DO228986	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.0833
p.N82K	DO229018	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.5806
p.S68R	DO229031	LICA	ICGC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.5556
p.D93G	SIDM00262	Ewing's Sarcoma	GDSC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.0556
p.D93G	ES6	bone	COSMIC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.0556
p.N82H	SIDM01051	Ovarian Carcinoma	GDSC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.6312
p.N82H	ACH-000936	Ovarian Cancer	CCLE	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.6312
p.N82H	EFO-27	ovary	COSMIC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.6312
p.K92E	ES6	bone	COSMIC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.1944
p.Q91P	ES6	bone	COSMIC	TPEDTPNK	DEG_SCF_SKP2-CKS1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TPEDTPNK

Degron related mutations and impact score

Drug responses associated with TGOLN2 mutations

All proteins holding degron of TPEDTPNK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43493	Trans-Golgi network integral membrane protein 2	DEG_SCF_SKP2-CKS1_1	76:83	TPEDTPNK	SKP2,CSK1	0.9934	More...