DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LQTPPAS
Uniprot ID:
Q9H6K5
Source protein:
Proline-rich protein 36
Source gene:
PRR36
Class:
DEG_SCF_FBW7_1
Location:
722:728
E3 ligase:
FBXW7
DEGRON score:
0.7808
ASA_SCORE:
90.1714
COIL:
0.9651
CONS_SCORE:
0
DSS_SCORE:
0.6991
HELIX:
0.0166
FCONS_SCORE:
0
RIG_SCORE:
0.5817
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PRR36 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQTPPAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6K5
Proline-rich protein 36
DEG_SCF_FBW7_1
722:728
LQTPPAS
FBXW7
0.7808
More...