DegronMD

Uniprot ID: A1E959

Source protein: Odontogenic ameloblast-associated protein

Source gene: ODAM

Class: DEG_SCF_FBW7_1

Location: 113:119

E3 ligase: FBXW7

DEGRON score: 0.8919

ASA_SCORE: 99.3571

COIL: 0.9484

CONS_SCORE: 0.8384

DSS_SCORE: 0.7089

HELIX: 0.0256

FCONS_SCORE: 1.1632

RIG_SCORE: 0.632

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G106C	TCGA-5R-AAAM	LIHC	TCGA	LQTPPQT	DEG_SCF_FBW7_1	0.1389
p.G106C	DO219549	LIHC	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.1389
p.V108G	TCGA-BR-A4PD	STAD	TCGA	LQTPPQT	DEG_SCF_FBW7_1	0.1944
p.V108G	DO47831	STAD	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.1944
p.Y129C	TCGA-DY-A1DG	READ	TCGA	LQTPPQT	DEG_SCF_FBW7_1	0.0556
p.Y129C	DO36853	READ	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.0556
p.S124I	TCGA-KD-A5QS	SARC	TCGA	LQTPPQT	DEG_SCF_FBW7_1	0.1944
p.S124I	DO223270	SARC	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.1944
p.G122C	TCGA-QK-A6IJ	HNSC	TCGA	LQTPPQT	DEG_SCF_FBW7_1	0.25
p.G122C	DO50008	HNSC	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.25
p.D109N	TCGA-XF-A9ST	BLCA	TCGA	LQTPPQT	DEG_SCF_FBW7_1	0.2222
p.D109N	DO223599	BLCA	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.2222
p.G122S	DO223412	CLLE	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.25
p.L111V	DO234199	ESAD	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.2778
p.V126L	DO229031	LICA	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.1389
p.V126L	DO229035	LICA	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.1389
p.A103S	DO229041	LICA	ICGC	LQTPPQT	DEG_SCF_FBW7_1	0.0556
p.G106D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LQTPPQT	DEG_SCF_FBW7_1	0.1389
p.G106D	ACH-000981	Leukemia	CCLE	LQTPPQT	DEG_SCF_FBW7_1	0.1389
p.G106D	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPPQT	DEG_SCF_FBW7_1	0.1389
p.T115I	SIDM00680	Colorectal Carcinoma	GDSC	LQTPPQT	DEG_SCF_FBW7_1	0.7078
p.T115I	ACH-000957	Colon/Colorectal Cancer	CCLE	LQTPPQT	DEG_SCF_FBW7_1	0.7078
p.T115I	LS-180	large_intestine	COSMIC	LQTPPQT	DEG_SCF_FBW7_1	0.7078
p.M127V	SIDM00505	Pancreatic Carcinoma	GDSC	LQTPPQT	DEG_SCF_FBW7_1	0.1111
p.M127V	MIA-PaCa-2	pancreas	COSMIC	LQTPPQT	DEG_SCF_FBW7_1	0.1111
p.Q107H	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LQTPPQT	DEG_SCF_FBW7_1	0.1667
p.Q107H	ACH-000945	Lung Cancer	CCLE	LQTPPQT	DEG_SCF_FBW7_1	0.1667
p.Q107H	NCI-H650	lung	COSMIC	LQTPPQT	DEG_SCF_FBW7_1	0.1667
p.P116Q	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LQTPPQT	DEG_SCF_FBW7_1	0.7035
p.P116Q	ACH-000951	Lung Cancer	CCLE	LQTPPQT	DEG_SCF_FBW7_1	0.7035
p.P116Q	NCI-H2342	lung	COSMIC	LQTPPQT	DEG_SCF_FBW7_1	0.7035
p.P110H	SIDM01173	Rhabdomyosarcoma	GDSC	LQTPPQT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQTPPQT

Degron related mutations and impact score

Drug responses associated with ODAM mutations

All proteins holding degron of LQTPPQT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1E959	Odontogenic ameloblast-associated protein	DEG_SCF_FBW7_1	113:119	LQTPPQT	FBXW7	0.8919	More...