DegronMD

Uniprot ID: P33993

Source protein: DNA replication licensing factor MCM7

Source gene: MCM7

Class: SCF_FBXL2

Location: 222:228

E3 ligase: FBXL2

DEGRON score: 0.7458

ASA_SCORE: 66.4

COIL: 0.4401

CONS_SCORE: 0.6793

DSS_SCORE: 0.3827

HELIX: 0.013

FCONS_SCORE: 0.9667

RIG_SCORE: 0.7912

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R225W	TCGA-A6-2686	COAD	TCGA	LQTRGSR	SCF_FBXL2	0.8634
p.R225W	DO7828	COAD	ICGC	LQTRGSR	SCF_FBXL2	0.8634
p.R225Q	NCI-H1417	lung	COSMIC	LQTRGSR	SCF_FBXL2	0.7329
p.K231N	SIDM00118	Colorectal Carcinoma	GDSC	LQTRGSR	SCF_FBXL2	0.6944
p.K231N	ACH-001081	Colon/Colorectal Cancer	CCLE	LQTRGSR	SCF_FBXL2	0.6944
p.K231N	HCC2998	large_intestine	COSMIC	LQTRGSR	SCF_FBXL2	0.6944
p.R231Q	KURAMOCHI	ovary	COSMIC	LQTRGSR	SCF_FBXL2	0.6944
p.S227F	SIDM00213	Thyroid Gland Carcinoma	GDSC	LQTRGSR	SCF_FBXL2	0.6871
p.S227F	FTC-133	thyroid	COSMIC	LQTRGSR	SCF_FBXL2	0.6871
p.R219W	TCGA-VQ-A8PP	STAD	TCGA	LQTRGSR	SCF_FBXL2	0.25
p.R219W	DO51774	STAD	ICGC	LQTRGSR	SCF_FBXL2	0.25
p.E234K	TCGA-FR-A7U9	SKCM	TCGA	LQTRGSR	SCF_FBXL2	0.1667
p.E234K	DO48546	SKCM	ICGC	LQTRGSR	SCF_FBXL2	0.1667

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33993	DNA replication licensing factor MCM7	SCF_FBXL2	222:228	LQTRGSR	FBXL2	0.7458	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons