DegronMD

Uniprot ID: Q5EBL4

Source protein: RILP-like protein 1

Source gene: RILPL1

Class: DEG_APCC_DBOX_1

Location: 243:251

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8605

ASA_SCORE: 94.3889

COIL: 0.0702

CONS_SCORE: 0.4144

DSS_SCORE: 0.5761

HELIX: 0.934

FCONS_SCORE: 1.1173

RIG_SCORE: 0.7104

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A245S	TCGA-AJ-A3BH	UCEC	TCGA	LRAELGKLR	DEG_APCC_DBOX_1	0.6477
p.R244Q	TCGA-AP-A1DH	UCEC	TCGA	LRAELGKLR	DEG_APCC_DBOX_1	0.7329
p.E252D	TCGA-EW-A1J5	BRCA	TCGA	LRAELGKLR	DEG_APCC_DBOX_1	0.3056
p.S259I	TCGA-FI-A2D5	UCEC	TCGA	LRAELGKLR	DEG_APCC_DBOX_1	0.5556
p.N249K	DO228976	LICA	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	0.6918
p.N253K	DO228976	LICA	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	0.2778
p.R235P	DO45537	LUSC	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	0.5556
p.R246C	DO38328	STAD	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	0.8301
p.Q251H	DO229208	THCA	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	0.7582
p.K234T	DO41752	UCEC	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	0.0833
p.R251Q	SIDM00539	Esophageal Carcinoma	GDSC	LRAELGKLR	DEG_APCC_DBOX_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5EBL4	RILP-like protein 1	DEG_APCC_DBOX_1	243:251	LRAELGKLR	APC,CDC20,FZR1	0.8605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons