DegronMD - Q5EBL4(RILPL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A245S	TCGA-AJ-A3BH	UCEC	TCGA	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation altering degron motif	0.6477
p.R244Q	TCGA-AP-A1DH	UCEC	TCGA	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation altering degron motif	0.7329
p.P292L	TCGA-BF-AAP0	SKCM	TCGA	PRFTLQELR	DEG_APCC_DBOX_1	292:300	Mutation altering degron motif	0.6471
p.E252D	TCGA-EW-A1J5	BRCA	TCGA	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation rewiring degron network	0.3056
p.E305K	TCGA-FD-A3B6	BLCA	TCGA	PRFTLQELR	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.1944
p.S259I	TCGA-FI-A2D5	UCEC	TCGA	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation blocking phosphorylation signal	0.5556
p.E308K	TCGA-HJ-7597	STAD	TCGA	PRFTLQELR	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.1111
p.N249K	DO228976	LICA	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation altering degron motif	0.6918
p.N253K	DO228976	LICA	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation rewiring degron network	0.2778
p.R235P	DO45537	LUSC	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation blocking phosphorylation signal	0.5556
p.R246C	DO38328	STAD	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation altering degron motif	0.8301
p.Q251H	DO229208	THCA	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation altering degron motif	0.7582
p.K234T	DO41752	UCEC	ICGC	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation rewiring degron network	0.0833
p.N290S	SIDM00971	Breast Carcinoma	GDSC	PRFTLQELR	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.2778
p.N290S	ZR-75-30	breast	COSMIC	PRFTLQELR	DEG_APCC_DBOX_1	292:300	Mutation rewiring degron network	0.2778
p.R251Q	SIDM00539	Esophageal Carcinoma	GDSC	LRAELGKLR	DEG_APCC_DBOX_1	243:251	Mutation altering degron motif	0.6218

Kaplan plot for RILPL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RILPL1

UniProt ID: Q5EBL4

Entrez ID: 353116

Protein name: RILP-like protein 1 (Rab-interacting lysosomal-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RILPL1 in