DegronMD

Uniprot ID: Q5EBL4

Source protein: RILP-like protein 1

Source gene: RILPL1

Class: DEG_APCC_DBOX_1

Location: 292:300

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9767

ASA_SCORE: 68.1889

COIL: 0.3786

CONS_SCORE: 0.8072

DSS_SCORE: 0.4021

HELIX: 0.5886

FCONS_SCORE: 1.3034

RIG_SCORE: 0.7935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P292L	TCGA-BF-AAP0	SKCM	TCGA	PRFTLQELR	DEG_APCC_DBOX_1	0.6471
p.E305K	TCGA-FD-A3B6	BLCA	TCGA	PRFTLQELR	DEG_APCC_DBOX_1	0.1944
p.E308K	TCGA-HJ-7597	STAD	TCGA	PRFTLQELR	DEG_APCC_DBOX_1	0.1111
p.N290S	SIDM00971	Breast Carcinoma	GDSC	PRFTLQELR	DEG_APCC_DBOX_1	0.2778
p.N290S	ZR-75-30	breast	COSMIC	PRFTLQELR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5EBL4	RILP-like protein 1	DEG_APCC_DBOX_1	292:300	PRFTLQELR	APC,CDC20,FZR1	0.9767	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons