DegronMD

Uniprot ID: P48788

Source protein: Troponin I, fast skeletal muscle

Source gene: TNNI2

Class: DEG_APCC_DBOX_1

Location: 137:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6703

ASA_SCORE: 79.5111

COIL: 0.4853

CONS_SCORE: 0.9087

DSS_SCORE: 0.3866

HELIX: 0.4503

FCONS_SCORE: 1.0459

RIG_SCORE: 0.7891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E150D	TCGA-55-8506	LUAD	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	0.1944
p.E150D	DO45390	LUAD	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	0.1944
p.N140K	TCGA-CD-A489	STAD	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	0.5806
p.N140K	DO47815	STAD	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	0.5806
p.K130N	TCGA-CM-6162	COAD	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	0.25
p.K130N	DO8479	COAD	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	0.25
p.K130N	SIDM01118	Small Cell Lung Carcinoma	GDSC	LRANLKQVK	DEG_APCC_DBOX_1	0.25
p.K130N	ACH-002175	Lung Cancer	CCLE	LRANLKQVK	DEG_APCC_DBOX_1	0.25
p.K130N	NCI-H740	lung	COSMIC	LRANLKQVK	DEG_APCC_DBOX_1	0.25
p.Q143P	TCGA-EO-A22U	UCEC	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	0.5924
p.Q143P	DO43755	UCEC	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	0.5924
p.K145N	TCGA-ER-A19F	SKCM	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	0.5806
p.K145N	DO37679	SKCM	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	0.5806
p.D136N	TCGA-GN-A26C	SKCM	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	0.3056
p.D136N	DO37782	SKCM	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	0.3056
p.T149I	DO229229	THCA	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	0.2222
p.K132T	SIDM00534	Colorectal Carcinoma	GDSC	LRANLKQVK	DEG_APCC_DBOX_1	0.3056
p.K132T	ACH-000986	Colon/Colorectal Cancer	CCLE	LRANLKQVK	DEG_APCC_DBOX_1	0.3056
p.K132T	HT-115	large_intestine	COSMIC	LRANLKQVK	DEG_APCC_DBOX_1	0.3056
p.V133E	ACH-001390	Breast Cancer	CCLE	LRANLKQVK	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48788	Troponin I, fast skeletal muscle	DEG_APCC_DBOX_1	137:145	LRANLKQVK	APC,CDC20,FZR1	0.6703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons