DegronMD - P48788(TNNI2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D102Y	TCGA-18-3411	LUSC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1667
p.D102Y	DO26758	LUSC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1667
p.E150D	TCGA-55-8506	LUAD	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1944
p.E150D	DO45390	LUAD	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1944
p.R104W	TCGA-AJ-A3BH	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.2222
p.R104W	DO41638	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.2222
p.D102N	TCGA-AJ-A3EL	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1667
p.D102N	DO41542	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1667
p.N140K	TCGA-CD-A489	STAD	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.5806
p.N140K	DO47815	STAD	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.5806
p.R113W	TCGA-CG-4306	STAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.7523
p.R113W	TCGA-ZS-A9CF	LIHC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.7523
p.R113W	DO49722	LIHC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.7523
p.R113W	DO38567	STAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.7523
p.K130N	TCGA-CM-6162	COAD	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.25
p.K130N	DO8479	COAD	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.25
p.K130N	SIDM01118	Small Cell Lung Carcinoma	GDSC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.25
p.K130N	ACH-002175	Lung Cancer	CCLE	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.25
p.K130N	NCI-H740	lung	COSMIC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.25
p.K108E	TCGA-DI-A1BU	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.591
p.K108E	DO42023	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.591
p.Q143P	TCGA-EO-A22U	UCEC	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.5924
p.Q143P	DO43755	UCEC	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.5924
p.K145N	TCGA-ER-A19F	SKCM	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.5806
p.K145N	DO37679	SKCM	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.5806
p.G105A	TCGA-F7-A624	HNSC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.25
p.G105A	DO44440	HNSC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.25
p.D136N	TCGA-GN-A26C	SKCM	TCGA	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.3056
p.D136N	DO37782	SKCM	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.3056
p.R113Q	DO222765	COCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.6218
p.V115L	DO229034	LICA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.5654
p.A119S	DO229041	LICA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.25
p.R104L	DO229008	LICA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.2222
p.V115M	DO229256	LMS	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.6097
p.D120V	DO25189	LUAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.2222
p.T149I	DO229229	THCA	ICGC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.2222
p.R116C	SIDM01314	Colorectal Carcinoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.719
p.K132T	SIDM00534	Colorectal Carcinoma	GDSC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.3056
p.K132T	ACH-000986	Colon/Colorectal Cancer	CCLE	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.3056
p.K132T	HT-115	large intestine	COSMIC	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.3056
p.V133E	ACH-001390	Breast Cancer	CCLE	LRANLKQVK	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNNI2

UniProt ID: P48788

Entrez ID: 7136

Protein name: Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNNI2 in