DegronMD

Uniprot ID: P48788

Source protein: Troponin I, fast skeletal muscle

Source gene: TNNI2

Class: DEG_APCC_DBOX_1

Location: 108:116

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8642

ASA_SCORE: 104.4222

COIL: 0.6333

CONS_SCORE: 0.9125

DSS_SCORE: 0.3819

HELIX: 0.2842

FCONS_SCORE: 1.018

RIG_SCORE: 0.7799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D102Y	TCGA-18-3411	LUSC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.1667
p.D102Y	DO26758	LUSC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.1667
p.R104W	TCGA-AJ-A3BH	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.2222
p.R104W	DO41638	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.2222
p.D102N	TCGA-AJ-A3EL	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.1667
p.D102N	DO41542	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.1667
p.R113W	TCGA-CG-4306	STAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.7523
p.R113W	TCGA-ZS-A9CF	LIHC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.7523
p.R113W	DO49722	LIHC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.7523
p.R113W	DO38567	STAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.7523
p.K108E	TCGA-DI-A1BU	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.591
p.K108E	DO42023	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.591
p.G105A	TCGA-F7-A624	HNSC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.25
p.G105A	DO44440	HNSC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.25
p.R113Q	DO222765	COCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.6218
p.V115L	DO229034	LICA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.5654
p.A119S	DO229041	LICA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.25
p.R104L	DO229008	LICA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.2222
p.V115M	DO229256	LMS	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.6097
p.D120V	DO25189	LUAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.2222
p.R116C	SIDM01314	Colorectal Carcinoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19237	Troponin I, slow skeletal muscle	DEG_APCC_DBOX_1	109:117	KRPPLRRVR	APC,CDC20,FZR1	0.9447	More...
P48788	Troponin I, fast skeletal muscle	DEG_APCC_DBOX_1	108:116	KRPPLRRVR	APC,CDC20,FZR1	0.8642	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons