DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
KRPPLRRVR
Uniprot ID:
P19237
Source protein:
Troponin I, slow skeletal muscle
Source gene:
TNNI1
Class:
DEG_APCC_DBOX_1
Location:
109:117
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9447
ASA_SCORE:
104.4556
COIL:
0.7737
CONS_SCORE:
0.7809
DSS_SCORE:
0.3176
HELIX:
0.1442
FCONS_SCORE:
1.17
RIG_SCORE:
0.793
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R110C
TCGA-AO-A12E
BRCA
TCGA
KRPPLRRVR
DEG_APCC_DBOX_1
0.8301
p.R110C
DO2521
BRCA
ICGC
KRPPLRRVR
DEG_APCC_DBOX_1
0.8301
p.R110H
TCGA-AA-3672
COAD
TCGA
KRPPLRRVR
DEG_APCC_DBOX_1
0.8244
p.R110H
DO9010
COAD
ICGC
KRPPLRRVR
DEG_APCC_DBOX_1
0.8244
p.L113P
SIDM01146
Gastric Carcinoma
GDSC
KRPPLRRVR
DEG_APCC_DBOX_1
0.7582
p.L113P
ACH-000932
Gastric Cancer
CCLE
KRPPLRRVR
DEG_APCC_DBOX_1
0.7582
p.L113P
NCI-SNU-1
stomach
COSMIC
KRPPLRRVR
DEG_APCC_DBOX_1
0.7582
p.R117C
TCGA-YL-A8S8
PRAD
TCGA
KRPPLRRVR
DEG_APCC_DBOX_1
0.719
p.R117C
DO51422
PRAD
ICGC
KRPPLRRVR
DEG_APCC_DBOX_1
0.719
p.R117H
SIDM01251
T-Cell Non-Hodgkin's Lymphoma
GDSC
KRPPLRRVR
DEG_APCC_DBOX_1
0.7133
p.R117H
ACH-000509
Lymphoma
CCLE
KRPPLRRVR
DEG_APCC_DBOX_1
0.7133
p.R117H
ACH-002240
Lymphoma
CCLE
KRPPLRRVR
DEG_APCC_DBOX_1
0.7133
p.R117H
H9
haematopoietic_and_lymphoid_tissue
COSMIC
KRPPLRRVR
DEG_APCC_DBOX_1
0.7133
p.P111L
TCGA-AP-A1DO
UCEC
TCGA
KRPPLRRVR
DEG_APCC_DBOX_1
0.6471
p.P111L
DO52430
COCA
ICGC
KRPPLRRVR
DEG_APCC_DBOX_1
0.6471
p.P111L
DO43250
UCEC
ICGC
KRPPLRRVR
DEG_APCC_DBOX_1
0.6471
p.R115Q
TCGA-A5-A0G2
UCEC
TCGA
KRPPLRRVR
DEG_APCC_DBOX_1
0.6218
p.R115Q
TCGA-AA-A01P
COAD
TCGA
KRPPLRRVR
DEG_APCC_DBOX_1
0.6218
p.R115Q
DO8642
COAD
ICGC
KRPPLRRVR
DEG_APCC_DBOX_1
0.6218
p.R115Q
DO41235
UCEC
ICGC
KRPPLRRVR
DEG_APCC_DBOX_1
0.6218
p.P111T
SIDM00927
Small Cell Lung Carcinoma
GDSC
KRPPLRRVR
DEG_APCC_DBOX_1
0.5919
p.P111T
ACH-000871
Lung Cancer
CCLE
KRPPLRRVR
DEG_APCC_DBOX_1
0.5919
p.P111T
NCI-H510A
lung
COSMIC
KRPPLRRVR
DEG_APCC_DBOX_1
0.5919
p.G106W
TCGA-CV-6933
HNSC
TCGA
KRPPLRRVR
DEG_APCC_DBOX_1
0.25
p.G106W
DO14164
HNSC
ICGC
KRPPLRRVR
DEG_APCC_DBOX_1
0.25
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Drug responses associated with TNNI1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of KRPPLRRVR
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P48788
Troponin I, fast skeletal muscle
DEG_APCC_DBOX_1
108:116
KRPPLRRVR
APC,CDC20,FZR1
0.8642
More...
P19237
Troponin I, slow skeletal muscle
DEG_APCC_DBOX_1
109:117
KRPPLRRVR
APC,CDC20,FZR1
0.9447
More...
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