DegronMD

Uniprot ID: P19237

Source protein: Troponin I, slow skeletal muscle

Source gene: TNNI1

Class: DEG_APCC_DBOX_1

Location: 109:117

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9447

ASA_SCORE: 104.4556

COIL: 0.7737

CONS_SCORE: 0.7809

DSS_SCORE: 0.3176

HELIX: 0.1442

FCONS_SCORE: 1.17

RIG_SCORE: 0.793

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R115Q	TCGA-A5-A0G2	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.6218
p.R115Q	TCGA-AA-A01P	COAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.6218
p.R115Q	DO8642	COAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.6218
p.R115Q	DO41235	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.6218
p.R110H	TCGA-AA-3672	COAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.8244
p.R110H	DO9010	COAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.8244
p.R110C	TCGA-AO-A12E	BRCA	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.8301
p.R110C	DO2521	BRCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.8301
p.P111L	TCGA-AP-A1DO	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.6471
p.P111L	DO52430	COCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.6471
p.P111L	DO43250	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.6471
p.R125P	TCGA-BR-8590	STAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.1111
p.R125P	DO47779	STAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.1111
p.G106W	TCGA-CV-6933	HNSC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.25
p.G106W	DO14164	HNSC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.25
p.M123V	TCGA-DI-A0WH	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.1667
p.M123V	DO43843	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.1667
p.D103E	TCGA-DK-AA6U	BLCA	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.1667
p.D103E	DO219008	BLCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.1667
p.R125W	TCGA-G2-A2EF	BLCA	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.1111
p.R125W	DO726	BLCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.1111
p.R125W	ACH-001719	Ovarian Cancer	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	0.1111
p.R105C	TCGA-W3-AA21	SKCM	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.2222
p.R105C	DO222702	MELA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.2222
p.R105C	DO51278	SKCM	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.2222
p.R117C	TCGA-YL-A8S8	PRAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	0.719
p.R117C	DO51422	PRAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.719
p.L104I	DO229038	LICA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.1944
p.G106E	DO222843	MELA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	0.25
p.M102L	SIDM00845	Burkitt's Lymphoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	0.1389
p.R117H	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	0.7133
p.R117H	ACH-000509	Lymphoma	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	0.7133
p.R117H	ACH-002240	Lymphoma	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	0.7133
p.R117H	H9	haematopoietic_and_lymphoid_tissue	COSMIC	KRPPLRRVR	DEG_APCC_DBOX_1	0.7133
p.L113P	SIDM01146	Gastric Carcinoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	0.7582
p.L113P	ACH-000932	Gastric Cancer	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	0.7582
p.L113P	NCI-SNU-1	stomach	COSMIC	KRPPLRRVR	DEG_APCC_DBOX_1	0.7582
p.P111T	SIDM00927	Small Cell Lung Carcinoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	0.5919
p.P111T	ACH-000871	Lung Cancer	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	0.5919
p.P111T	NCI-H510A	lung	COSMIC	KRPPLRRVR	DEG_APCC_DBOX_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19237	Troponin I, slow skeletal muscle	DEG_APCC_DBOX_1	109:117	KRPPLRRVR	APC,CDC20,FZR1	0.9447	More...
P48788	Troponin I, fast skeletal muscle	DEG_APCC_DBOX_1	108:116	KRPPLRRVR	APC,CDC20,FZR1	0.8642	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRPPLRRVR

Degron related mutations and impact score

Drug responses associated with TNNI1 mutations

All proteins holding degron of KRPPLRRVR