DegronMD - P19237(TNNI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R139W	TCGA-14-1827	GBM	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.8634
p.R139W	DO12046	GBM	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.8634
p.R139W	SIDM02021	Esophageal Carcinoma	GDSC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.8634
p.H132Q	TCGA-21-1083	LUSC	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1667
p.H132Q	DO26769	LUSC	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1667
p.R115Q	TCGA-A5-A0G2	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6218
p.R115Q	TCGA-AA-A01P	COAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6218
p.R115Q	DO8642	COAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6218
p.R115Q	DO41235	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6218
p.R110H	TCGA-AA-3672	COAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.8244
p.R110H	DO9010	COAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.8244
p.R110C	TCGA-AO-A12E	BRCA	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.8301
p.R110C	DO2521	BRCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.8301
p.P111L	TCGA-AP-A1DO	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6471
p.P111L	DO52430	COCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6471
p.P111L	DO43250	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.6471
p.R125P	TCGA-BR-8590	STAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1111
p.R125P	DO47779	STAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1111
p.G106W	TCGA-CV-6933	HNSC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.25
p.G106W	DO14164	HNSC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.25
p.M123V	TCGA-DI-A0WH	UCEC	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.M123V	DO43843	UCEC	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.D103E	TCGA-DK-AA6U	BLCA	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.D103E	DO219008	BLCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1667
p.S144Y	TCGA-EO-A22R	UCEC	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6009
p.S144Y	DO42713	UCEC	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6009
p.R154L	TCGA-FS-A1ZG	SKCM	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1111
p.R154L	DO37523	SKCM	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1111
p.R125W	TCGA-G2-A2EF	BLCA	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1111
p.R125W	DO726	BLCA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1111
p.R125W	ACH-001719	Ovarian Cancer	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1111
p.R105C	TCGA-W3-AA21	SKCM	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.2222
p.R105C	DO222702	MELA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.2222
p.R105C	DO51278	SKCM	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.2222
p.S130F	TCGA-XF-A9T0	BLCA	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1111
p.S130F	DO51920	BLCA	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1111
p.R117C	TCGA-YL-A8S8	PRAD	TCGA	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.719
p.R117C	DO51422	PRAD	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.719
p.V145M	DO233944	GACA	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6097
p.V145M	DO229248	THCA	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6097
p.L104I	DO229038	LICA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1944
p.G106E	DO222843	MELA	ICGC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.25
p.E148D	DO36556	READ	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2778
p.M102L	SIDM00845	Burkitt's Lymphoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation rewiring degron network	0.1389
p.R117H	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7133
p.R117H	ACH-000509	Lymphoma	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7133
p.R117H	ACH-002240	Lymphoma	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7133
p.R117H	H9	haematopoietic and lymphoid tissue	COSMIC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7133
p.L113P	SIDM01146	Gastric Carcinoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7582
p.L113P	ACH-000932	Gastric Cancer	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7582
p.L113P	NCI-SNU-1	stomach	COSMIC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.7582
p.P111T	SIDM00927	Small Cell Lung Carcinoma	GDSC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.5919
p.P111T	ACH-000871	Lung Cancer	CCLE	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.5919
p.P111T	NCI-H510A	lung	COSMIC	KRPPLRRVR	DEG_APCC_DBOX_1	109:117	Mutation altering degron motif	0.5919
p.R154Q	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1111
p.R154Q	ACH-000343	Lung Cancer	CCLE	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1111
p.R154Q	NCI-H522	lung	COSMIC	LRANLKSVK	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNNI1

UniProt ID: P19237

Entrez ID: 7135

Protein name: Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNNI1 in