DegronMD

Uniprot ID: P19237

Source protein: Troponin I, slow skeletal muscle

Source gene: TNNI1

Class: DEG_APCC_DBOX_1

Location: 138:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9821

ASA_SCORE: 81.9667

COIL: 0.4866

CONS_SCORE: 0.7749

DSS_SCORE: 0.4742

HELIX: 0.3876

FCONS_SCORE: 1.6489

RIG_SCORE: 0.7411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R139W	TCGA-14-1827	GBM	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	0.8634
p.R139W	DO12046	GBM	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	0.8634
p.R139W	SIDM02021	Esophageal Carcinoma	GDSC	LRANLKSVK	DEG_APCC_DBOX_1	0.8634
p.H132Q	TCGA-21-1083	LUSC	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	0.1667
p.H132Q	DO26769	LUSC	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	0.1667
p.S144Y	TCGA-EO-A22R	UCEC	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	0.6009
p.S144Y	DO42713	UCEC	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	0.6009
p.R154L	TCGA-FS-A1ZG	SKCM	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	0.1111
p.R154L	DO37523	SKCM	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	0.1111
p.S130F	TCGA-XF-A9T0	BLCA	TCGA	LRANLKSVK	DEG_APCC_DBOX_1	0.1111
p.S130F	DO51920	BLCA	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	0.1111
p.V145M	DO233944	GACA	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	0.6097
p.V145M	DO229248	THCA	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	0.6097
p.E148D	DO36556	READ	ICGC	LRANLKSVK	DEG_APCC_DBOX_1	0.2778
p.R154Q	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	LRANLKSVK	DEG_APCC_DBOX_1	0.1111
p.R154Q	ACH-000343	Lung Cancer	CCLE	LRANLKSVK	DEG_APCC_DBOX_1	0.1111
p.R154Q	NCI-H522	lung	COSMIC	LRANLKSVK	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19237	Troponin I, slow skeletal muscle	DEG_APCC_DBOX_1	138:146	LRANLKSVK	APC,CDC20,FZR1	0.9821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons