DegronMD

Uniprot ID: Q9NSI2

Source protein: Ribosome biogenesis protein SLX9 homolog

Source gene: SLX9

Class: DEG_APCC_DBOX_1

Location: 147:155

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9846

ASA_SCORE: 59.5333

COIL: 0.2782

CONS_SCORE: 0.7877

DSS_SCORE: 0.4025

HELIX: 0.7111

FCONS_SCORE: 1.2593

RIG_SCORE: 0.7655

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R148H	ACH-000989	Colon/Colorectal Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	0.8244
p.S155N	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	0.7069
p.S161R	TCGA-CH-5789	PRAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161R	DO36265	PRAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO222972	BTCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229013	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229016	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229005	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229346	LAML	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229489	LAML	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO52365	LUSC	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.A150T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.6028
p.A150T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	0.6028
p.E153K	TCGA-BR-7851	STAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.591
p.E153K	DO38711	STAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.591
p.D149N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.5821
p.D149N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	0.5821
p.T138M	SIDM01156	Small Cell Lung Carcinoma	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.5278
p.T138M	SIDM00151	Ovarian Carcinoma	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.5278
p.L157P	TCGA-EY-A2OM	UCEC	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.2778
p.L157P	DO43025	UCEC	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.2778
p.L157H	DO229208	THCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.2778
p.A144V	ACH-000961	Endometrial/Uterine Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	0.25
p.R159W	ACH-000891	Lung Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	0.2222
p.G142V	TCGA-EB-A299	SKCM	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.1944

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Drug responses associated with SLX9 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRDALPELL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSI2	Ribosome biogenesis protein SLX9 homolog	DEG_APCC_DBOX_1	147:155	LRDALPELL	APC,CDC20,FZR1	0.9846	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRDALPELL

Degron related mutations and impact score

Drug responses associated with SLX9 mutations

All proteins holding degron of LRDALPELL