DegronMD

Uniprot ID: Q9NSI2

Source protein: Ribosome biogenesis protein SLX9 homolog

Source gene: SLX9

Class: DEG_APCC_DBOX_1

Location: 147:155

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9846

ASA_SCORE: 59.5333

COIL: 0.2782

CONS_SCORE: 0.7877

DSS_SCORE: 0.4025

HELIX: 0.7111

FCONS_SCORE: 1.2593

RIG_SCORE: 0.7655

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A165V	TCGA-AD-6964	COAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.0556
p.A165V	DO8360	COAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.0556
p.E153K	TCGA-BR-7851	STAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.591
p.E153K	DO38711	STAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.591
p.S161R	TCGA-CH-5789	PRAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161R	DO36265	PRAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.G142V	TCGA-EB-A299	SKCM	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.1944
p.G142V	DO37794	SKCM	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.1944
p.L157P	TCGA-EY-A2OM	UCEC	TCGA	LRDALPELL	DEG_APCC_DBOX_1	0.2778
p.L157P	DO43025	UCEC	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.2778
p.S161I	DO222972	BTCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229013	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229016	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229005	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229346	LAML	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO229489	LAML	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.S161I	DO52365	LUSC	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.6111
p.L157H	DO229208	THCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	0.2778
p.R163H	SIDM00216	Colorectal Carcinoma	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.1111
p.T138M	SIDM01156	Small Cell Lung Carcinoma	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.5278
p.T138M	SIDM00151	Ovarian Carcinoma	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.5278
p.D149N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.5821
p.D149N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	0.5821
p.A150T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LRDALPELL	DEG_APCC_DBOX_1	0.6028
p.A150T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	0.6028
p.R159W	ACH-000891	Lung Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	0.2222
p.A144V	ACH-000961	Endometrial/Uterine Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	0.25
p.R148H	ACH-000989	Colon/Colorectal Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	0.8244
p.S155N	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	0.7069
p.V139A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRDALPELL

Degron related mutations and impact score

Drug responses associated with SLX9 mutations

All proteins holding degron of LRDALPELL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSI2	Ribosome biogenesis protein SLX9 homolog	DEG_APCC_DBOX_1	147:155	LRDALPELL	APC,CDC20,FZR1	0.9846	More...