DegronMD - Q9NSI2(SLX9)

FUNCTION: May be involved in ribosome biogenesis. {ECO:0000250|UniProtKB:P53251}.

GO - Biological processes (BP): maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]

GO - Molecular function (MF):

GO - Cellular component (CC): 90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S84L	TCGA-EO-A3B0	UCEC	TCGA	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.8778
p.S84L	DO219773	UCEC	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.8778
p.R148H	ACH-000989	Colon/Colorectal Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.8244
p.R87W	TCGA-D3-A51E	SKCM	TCGA	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7523
p.R87W	DO47465	SKCM	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7523
p.V89I	SIDM01943	Colorectal Carcinoma	GDSC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7076
p.V86I	COLO-792	skin	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7076
p.V86I	NCI-H1694	lung	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7076
p.V86I	PF-382	haematopoietic and lymphoid tissue	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7076
p.S155N	REH	haematopoietic and lymphoid tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.7069
p.R87Q	SIDM01048	Plasma Cell Myeloma	GDSC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.6218
p.R87Q	ACH-000821	Myeloma	CCLE	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.6218
p.R87Q	EJM	haematopoietic and lymphoid tissue	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.6218
p.S161R	TCGA-CH-5789	PRAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161R	DO36265	PRAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO222972	BTCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229013	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229016	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229005	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229346	LAML	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111

Showing 1 to 20 of 61 entries

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Kaplan plot for SLX9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLX9

UniProt ID: Q9NSI2

Entrez ID: 85395

Protein name: Ribosome biogenesis protein SLX9 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLX9 in