DegronMD - Q9NSI2(SLX9)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K99N	TCGA-37-3792	LUSC	TCGA	SSARSVPSI	DEG_COP1_1	84:92	Mutation blocking ubiquitination signal	0.5833
p.K99N	DO27192	LUSC	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation blocking ubiquitination signal	0.5833
p.A165V	TCGA-AD-6964	COAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.0556
p.A165V	DO8360	COAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.0556
p.V74A	TCGA-BH-A18G	BRCA	TCGA	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0556
p.V74A	DO3686	BRCA	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0556
p.E153K	TCGA-BR-7851	STAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.591
p.E153K	DO38711	STAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.591
p.I92V	TCGA-BS-A0UJ	UCEC	TCGA	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.5965
p.I92V	DO42745	UCEC	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.5965
p.S161R	TCGA-CH-5789	PRAD	TCGA	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161R	DO36265	PRAD	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.R87W	TCGA-D3-A51E	SKCM	TCGA	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7523
p.R87W	DO47465	SKCM	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7523
p.G142V	TCGA-EB-A299	SKCM	TCGA	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1944
p.G142V	DO37794	SKCM	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1944
p.S84L	TCGA-EO-A3B0	UCEC	TCGA	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.8778
p.S84L	DO219773	UCEC	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.8778
p.L157P	TCGA-EY-A2OM	UCEC	TCGA	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.L157P	DO43025	UCEC	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.V77I	TCGA-J9-A52C	PRAD	TCGA	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.1389
p.V77I	DO51343	PRAD	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.1389
p.V77I	SIDM01756	Chronic Myelogenous Leukemia	GDSC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.1389
p.V77I	ACH-000076	Leukemia	CCLE	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.1389
p.S161I	DO222972	BTCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229013	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229016	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229005	COCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229346	LAML	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO229489	LAML	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.S161I	DO52365	LUSC	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.V101F	DO228978	LICA	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0833
p.T100I	DO218856	SKCA	ICGC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.1111
p.L157H	DO229208	THCA	ICGC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.V89I	SIDM01943	Colorectal Carcinoma	GDSC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7076
p.R163H	SIDM00216	Colorectal Carcinoma	GDSC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1111
p.T138M	SIDM01156	Small Cell Lung Carcinoma	GDSC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.5278
p.T138M	SIDM00151	Ovarian Carcinoma	GDSC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.5278
p.R87Q	SIDM01048	Plasma Cell Myeloma	GDSC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.6218
p.R87Q	ACH-000821	Myeloma	CCLE	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.6218
p.R87Q	EJM	haematopoietic and lymphoid tissue	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.6218
p.D149N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.5821
p.D149N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.5821
p.V101I	SIDM00741	Small Cell Lung Carcinoma	GDSC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0833
p.V101I	SIDM00140	Melanoma	GDSC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0833
p.V101I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0833
p.V101I	COLO-792	skin	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0833
p.V101I	NCI-H1694	lung	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0833
p.V101I	PF-382	haematopoietic and lymphoid tissue	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.0833
p.A150T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.6028
p.A150T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.6028
p.R159W	ACH-000891	Lung Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2222
p.R97C	ACH-000929	Lung Cancer	CCLE	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.1944
p.R97C	NCI-H2110	lung	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation rewiring degron network	0.1944
p.A144V	ACH-000961	Endometrial/Uterine Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.25
p.R148H	ACH-000989	Colon/Colorectal Cancer	CCLE	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.8244
p.V86I	COLO-792	skin	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7076
p.V86I	NCI-H1694	lung	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7076
p.V86I	PF-382	haematopoietic and lymphoid tissue	COSMIC	SSARSVPSI	DEG_COP1_1	84:92	Mutation altering degron motif	0.7076
p.S155N	REH	haematopoietic and lymphoid tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.7069
p.V139A	PF-382	haematopoietic and lymphoid tissue	COSMIC	LRDALPELL	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLX9

UniProt ID: Q9NSI2

Entrez ID: 85395

Protein name: Ribosome biogenesis protein SLX9 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLX9 in