DegronMD

Uniprot ID: Q9NSI2

Source protein: Ribosome biogenesis protein SLX9 homolog

Source gene: SLX9

Class: DEG_COP1_1

Location: 84:92

E3 ligase: COP1

DEGRON score: 0.9939

ASA_SCORE: 74.5222

COIL: 0.79

CONS_SCORE: 0.1756

DSS_SCORE: 0.5212

HELIX: 0.1077

FCONS_SCORE: 0.4074

RIG_SCORE: 0.6447

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K99N	TCGA-37-3792	LUSC	TCGA	SSARSVPSI	DEG_COP1_1	0.5833
p.K99N	DO27192	LUSC	ICGC	SSARSVPSI	DEG_COP1_1	0.5833
p.V74A	TCGA-BH-A18G	BRCA	TCGA	SSARSVPSI	DEG_COP1_1	0.0556
p.V74A	DO3686	BRCA	ICGC	SSARSVPSI	DEG_COP1_1	0.0556
p.I92V	TCGA-BS-A0UJ	UCEC	TCGA	SSARSVPSI	DEG_COP1_1	0.5965
p.I92V	DO42745	UCEC	ICGC	SSARSVPSI	DEG_COP1_1	0.5965
p.R87W	TCGA-D3-A51E	SKCM	TCGA	SSARSVPSI	DEG_COP1_1	0.7523
p.R87W	DO47465	SKCM	ICGC	SSARSVPSI	DEG_COP1_1	0.7523
p.S84L	TCGA-EO-A3B0	UCEC	TCGA	SSARSVPSI	DEG_COP1_1	0.8778
p.S84L	DO219773	UCEC	ICGC	SSARSVPSI	DEG_COP1_1	0.8778
p.V77I	TCGA-J9-A52C	PRAD	TCGA	SSARSVPSI	DEG_COP1_1	0.1389
p.V77I	DO51343	PRAD	ICGC	SSARSVPSI	DEG_COP1_1	0.1389
p.V77I	SIDM01756	Chronic Myelogenous Leukemia	GDSC	SSARSVPSI	DEG_COP1_1	0.1389
p.V77I	ACH-000076	Leukemia	CCLE	SSARSVPSI	DEG_COP1_1	0.1389
p.V101F	DO228978	LICA	ICGC	SSARSVPSI	DEG_COP1_1	0.0833
p.T100I	DO218856	SKCA	ICGC	SSARSVPSI	DEG_COP1_1	0.1111
p.V89I	SIDM01943	Colorectal Carcinoma	GDSC	SSARSVPSI	DEG_COP1_1	0.7076
p.R87Q	SIDM01048	Plasma Cell Myeloma	GDSC	SSARSVPSI	DEG_COP1_1	0.6218
p.R87Q	ACH-000821	Myeloma	CCLE	SSARSVPSI	DEG_COP1_1	0.6218
p.R87Q	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	SSARSVPSI	DEG_COP1_1	0.6218
p.V101I	SIDM00741	Small Cell Lung Carcinoma	GDSC	SSARSVPSI	DEG_COP1_1	0.0833
p.V101I	SIDM00140	Melanoma	GDSC	SSARSVPSI	DEG_COP1_1	0.0833
p.V101I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	SSARSVPSI	DEG_COP1_1	0.0833
p.V101I	COLO-792	skin	COSMIC	SSARSVPSI	DEG_COP1_1	0.0833
p.V101I	NCI-H1694	lung	COSMIC	SSARSVPSI	DEG_COP1_1	0.0833
p.V101I	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	SSARSVPSI	DEG_COP1_1	0.0833
p.R97C	ACH-000929	Lung Cancer	CCLE	SSARSVPSI	DEG_COP1_1	0.1944
p.R97C	NCI-H2110	lung	COSMIC	SSARSVPSI	DEG_COP1_1	0.1944
p.V86I	COLO-792	skin	COSMIC	SSARSVPSI	DEG_COP1_1	0.7076
p.V86I	NCI-H1694	lung	COSMIC	SSARSVPSI	DEG_COP1_1	0.7076
p.V86I	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	SSARSVPSI	DEG_COP1_1	0.7076

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSARSVPSI

Degron related mutations and impact score

Drug responses associated with SLX9 mutations

All proteins holding degron of SSARSVPSI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSI2	Ribosome biogenesis protein SLX9 homolog	DEG_COP1_1	84:92	SSARSVPSI	COP1	0.9939	More...