DegronMD

Uniprot ID: P26006

Source protein: Integrin alpha-3

Source gene: ITGA3

Class: DEG_APCC_DBOX_1

Location: 561:569

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7293

ASA_SCORE: 65.6889

COIL: 0.6183

CONS_SCORE: 0.4723

DSS_SCORE: 0.0625

HELIX: 0.0826

FCONS_SCORE: 1.2103

RIG_SCORE: 0.8668

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R562L	DO229019	LICA	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	0.8428
p.R562C	DO231685	LINC	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	0.8301
p.R562C	ACH-001518	Endometrial/Uterine Cancer	CCLE	LRDKLRPII	DEG_APCC_DBOX_1	0.8301
p.R566H	DO234330	ESAD	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	0.7133
p.N560H	TCGA-61-1727	OV	TCGA	LRDKLRPII	DEG_APCC_DBOX_1	0.3056
p.N560H	DO29960	OV	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	0.3056
p.S571F	TCGA-EE-A29E	SKCM	TCGA	LRDKLRPII	DEG_APCC_DBOX_1	0.2778
p.S571F	DO37831	SKCM	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	0.2778
p.P577L	TCGA-EY-A2ON	UCEC	TCGA	LRDKLRPII	DEG_APCC_DBOX_1	0.1111
p.P577L	DO42849	UCEC	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	0.1111
p.R579Q	DO230326	COCA	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	0.0556

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26006	Integrin alpha-3	DEG_APCC_DBOX_1	561:569	LRDKLRPII	APC,CDC20,FZR1	0.7293	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons