DegronMD - P26006(ITGA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P581L	TCGA-44-7660	LUAD	TCGA	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation rewiring degron network	0.25
p.P581L	DO23834	LUAD	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation rewiring degron network	0.25
p.N560H	TCGA-61-1727	OV	TCGA	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.3056
p.N560H	DO29960	OV	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.3056
p.S571F	TCGA-EE-A29E	SKCM	TCGA	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.2778
p.S571F	DO37831	SKCM	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.2778
p.P577L	TCGA-EY-A2ON	UCEC	TCGA	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1111
p.P577L	TCGA-EY-A2ON	UCEC	TCGA	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation rewiring degron network	0.1389
p.P577L	DO42849	UCEC	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1111
p.P577L	DO42849	UCEC	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation rewiring degron network	0.1389
p.R585W	TCGA-OD-A75X	SKCM	TCGA	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation altering degron motif	0.8634
p.R585W	DO48601	SKCM	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation altering degron motif	0.8634
p.R579Q	DO230326	COCA	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.0556
p.R579Q	DO230326	COCA	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation rewiring degron network	0.1944
p.R566H	DO234330	ESAD	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7133
p.Q601H	DO228948	LICA	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation rewiring degron network	0.0833
p.R589L	DO228986	LICA	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	584:592	Mutation altering degron motif	0.7316
p.R562L	DO229019	LICA	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.8428
p.R562C	DO231685	LINC	ICGC	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.8301
p.R562C	ACH-001518	Endometrial/Uterine Cancer	CCLE	LRDKLRPII	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.8301

Kaplan plot for ITGA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGA3

UniProt ID: P26006

Entrez ID: 3675

Protein name: Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGA3 in