DegronMD

Uniprot ID: P26006

Source protein: Integrin alpha-3

Source gene: ITGA3

Class: DEG_APCC_DBOX_1

Location: 584:592

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.876

ASA_SCORE: 82.4444

COIL: 0.8051

CONS_SCORE: 0.3386

DSS_SCORE: 0.2855

HELIX: 0.1132

FCONS_SCORE: 0.834

RIG_SCORE: 0.7461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P581L	TCGA-44-7660	LUAD	TCGA	PRLGLRSLD	DEG_APCC_DBOX_1	0.25
p.P581L	DO23834	LUAD	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	0.25
p.P577L	TCGA-EY-A2ON	UCEC	TCGA	PRLGLRSLD	DEG_APCC_DBOX_1	0.1389
p.P577L	DO42849	UCEC	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	0.1389
p.R585W	TCGA-OD-A75X	SKCM	TCGA	PRLGLRSLD	DEG_APCC_DBOX_1	0.8634
p.R585W	DO48601	SKCM	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	0.8634
p.R579Q	DO230326	COCA	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	0.1944
p.Q601H	DO228948	LICA	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	0.0833
p.R589L	DO228986	LICA	ICGC	PRLGLRSLD	DEG_APCC_DBOX_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26006	Integrin alpha-3	DEG_APCC_DBOX_1	584:592	PRLGLRSLD	APC,CDC20,FZR1	0.876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons