DegronMD

Uniprot ID: Q14159

Source protein: DNA repair-scaffolding protein

Source gene: SPIDR

Class: DEG_APCC_DBOX_1

Location: 461:469

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5231

ASA_SCORE: 54.2778

COIL: 0.2706

CONS_SCORE: 0.3903

DSS_SCORE: 0.4049

HELIX: 0.7042

FCONS_SCORE: 1.2341

RIG_SCORE: 0.8156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D467Y	TCGA-68-8250	LUSC	TCGA	LRDSLLDVV	DEG_APCC_DBOX_1	0.6214
p.W477R	TCGA-BF-AAP8	SKCM	TCGA	LRDSLLDVV	DEG_APCC_DBOX_1	0.1111
p.R454C	TCGA-G4-6306	COAD	TCGA	LRDSLLDVV	DEG_APCC_DBOX_1	0.1389
p.R454C	TCGA-HU-A4GT	STAD	TCGA	LRDSLLDVV	DEG_APCC_DBOX_1	0.1389
p.R454C	SIDM00217	Colorectal Carcinoma	GDSC	LRDSLLDVV	DEG_APCC_DBOX_1	0.1389
p.R454C	SNU-1040	large_intestine	COSMIC	LRDSLLDVV	DEG_APCC_DBOX_1	0.1389
p.C454W	DO9002	COAD	ICGC	LRDSLLDVV	DEG_APCC_DBOX_1	0.1389
p.S467L	DO8264	COAD	ICGC	LRDSLLDVV	DEG_APCC_DBOX_1	0.7667
p.E463D	DO229037	LICA	ICGC	LRDSLLDVV	DEG_APCC_DBOX_1	0.6758
p.E459G	DO26530	LUSC	ICGC	LRDSLLDVV	DEG_APCC_DBOX_1	0.2778
p.M476T	ACH-001303	Neuroblastoma	CCLE	LRDSLLDVV	DEG_APCC_DBOX_1	0.1389
p.G458S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LRDSLLDVV	DEG_APCC_DBOX_1	0.25
p.G468S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LRDSLLDVV	DEG_APCC_DBOX_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14159	DNA repair-scaffolding protein	DEG_APCC_DBOX_1	461:469	LRDSLLDVV	APC,CDC20,FZR1	0.5231	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons