DegronMD - Q14159(SPIDR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q239E	TCGA-22-5471	LUSC	TCGA	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1389
p.Q239E	TCGA-5L-AAT1	BRCA	TCGA	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1389
p.D467Y	TCGA-68-8250	LUSC	TCGA	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation altering degron motif	0.6214
p.A243G	TCGA-AA-3666	COAD	TCGA	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.25
p.A243G	DO9042	COAD	ICGC	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.25
p.P246S	TCGA-AP-A0LM	UCEC	TCGA	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.6752
p.P246S	TCGA-FW-A3R5	SKCM	TCGA	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.6752
p.W477R	TCGA-BF-AAP8	SKCM	TCGA	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.1111
p.K255N	TCGA-CN-4729	HNSC	TCGA	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation substituting flanking lysine	0.3611
p.K255N	DO16029	HNSC	ICGC	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation substituting flanking lysine	0.3611
p.P238H	TCGA-FP-A4BE	STAD	TCGA	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1111
p.R454C	TCGA-G4-6306	COAD	TCGA	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.1389
p.R454C	TCGA-HU-A4GT	STAD	TCGA	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.1389
p.R454C	SIDM00217	Colorectal Carcinoma	GDSC	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.1389
p.R454C	SNU-1040	large intestine	COSMIC	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.1389
p.C454W	DO9002	COAD	ICGC	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.1389
p.S467L	DO8264	COAD	ICGC	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation altering degron motif	0.7667
p.E248V	DO234358	ESAD	ICGC	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.7693
p.A241S	DO229022	LICA	ICGC	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1944
p.E463D	DO229037	LICA	ICGC	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation altering degron motif	0.6758
p.E459G	DO26530	LUSC	ICGC	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.2778
p.A245V	DO47769	STAD	ICGC	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.3056
p.M476T	ACH-001303	Neuroblastoma	CCLE	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.1389
p.L261M	ACH-001820	Breast Cancer	CCLE	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.0833
p.L261M	COLO-824	breast	COSMIC	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.0833
p.L251M	COLO-824	breast	COSMIC	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.711
p.G458S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation rewiring degron network	0.25
p.G468S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LRDSLLDVV	DEG_APCC_DBOX_1	461:469	Mutation altering degron motif	0.6993
p.V261M	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PRTPENS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.0833

Kaplan plot for SPIDR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPIDR

UniProt ID: Q14159

Entrez ID: 23514

Protein name: DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPIDR in