DegronMD

Uniprot ID: Q14159

Source protein: DNA repair-scaffolding protein

Source gene: SPIDR

Class: DEG_SCF_FBW7_1

Location: 246:252

E3 ligase: FBXW7

DEGRON score: 0.9484

ASA_SCORE: 92.6

COIL: 0.7866

CONS_SCORE: 0.4905

DSS_SCORE: 0.6838

HELIX: 0.1916

FCONS_SCORE: 1.0459

RIG_SCORE: 0.6726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q239E	TCGA-22-5471	LUSC	TCGA	PRTPENS	DEG_SCF_FBW7_1	0.1389
p.Q239E	TCGA-5L-AAT1	BRCA	TCGA	PRTPENS	DEG_SCF_FBW7_1	0.1389
p.A243G	TCGA-AA-3666	COAD	TCGA	PRTPENS	DEG_SCF_FBW7_1	0.25
p.A243G	DO9042	COAD	ICGC	PRTPENS	DEG_SCF_FBW7_1	0.25
p.P246S	TCGA-AP-A0LM	UCEC	TCGA	PRTPENS	DEG_SCF_FBW7_1	0.6752
p.P246S	TCGA-FW-A3R5	SKCM	TCGA	PRTPENS	DEG_SCF_FBW7_1	0.6752
p.K255N	TCGA-CN-4729	HNSC	TCGA	PRTPENS	DEG_SCF_FBW7_1	0.3611
p.K255N	DO16029	HNSC	ICGC	PRTPENS	DEG_SCF_FBW7_1	0.3611
p.P238H	TCGA-FP-A4BE	STAD	TCGA	PRTPENS	DEG_SCF_FBW7_1	0.1111
p.E248V	DO234358	ESAD	ICGC	PRTPENS	DEG_SCF_FBW7_1	0.7693
p.A241S	DO229022	LICA	ICGC	PRTPENS	DEG_SCF_FBW7_1	0.1944
p.A245V	DO47769	STAD	ICGC	PRTPENS	DEG_SCF_FBW7_1	0.3056
p.L261M	ACH-001820	Breast Cancer	CCLE	PRTPENS	DEG_SCF_FBW7_1	0.0833
p.L261M	COLO-824	breast	COSMIC	PRTPENS	DEG_SCF_FBW7_1	0.0833
p.L251M	COLO-824	breast	COSMIC	PRTPENS	DEG_SCF_FBW7_1	0.711
p.V261M	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPENS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14159	DNA repair-scaffolding protein	DEG_SCF_FBW7_1	246:252	PRTPENS	FBXW7	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons