DegronMD

Uniprot ID: P32927

Source protein: Cytokine receptor common subunit beta

Source gene: CSF2RB

Class: DEG_APCC_DBOX_1

Location: 293:301

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7577

ASA_SCORE: 80.7778

COIL: 0.6062

CONS_SCORE: 0.2605

DSS_SCORE: 0.4195

HELIX: 0.0338

FCONS_SCORE: 0.6995

RIG_SCORE: 0.6684

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G298S	TCGA-12-0619	GBM	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.5882
p.G298S	TCGA-12-0692	GBM	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.5882
p.G298S	DO12898	GBM	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.5882
p.G298S	DO14025	GBM	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.5882
p.P311H	TCGA-55-6969	LUAD	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.0556
p.H301Q	TCGA-55-8089	LUAD	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.647
p.P311S	TCGA-CZ-4864	KIRC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.0556
p.C306R	TCGA-D1-A17M	UCEC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.1944
p.C306R	DO43779	UCEC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.1944
p.D283N	TCGA-D3-A3C8	SKCM	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.0556
p.D283N	DO47636	SKCM	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.0556
p.P309L	TCGA-D6-6516	HNSC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.1111
p.P309L	DO15623	HNSC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.1111
p.G285W	TCGA-DF-A2KU	UCEC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.1111
p.H301N	TCGA-EO-A3AV	UCEC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.6312
p.H301Y	TCGA-FI-A2D0	UCEC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.6118
p.H301Y	DO43891	UCEC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.6118
p.V310M	TCGA-KO-8408	KICH	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.0833
p.E286K	TCGA-RP-A695	SKCM	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	0.1389
p.E286K	DO51270	SKCM	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.1389
p.E286K	SIDM00973	Melanoma	GDSC	LREGLGSLH	DEG_APCC_DBOX_1	0.1389
p.E286K	WM793B	skin	COSMIC	LREGLGSLH	DEG_APCC_DBOX_1	0.1389
p.A288S	DO228936	LICA	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.1944
p.E295K	DO222402	MELA	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.591
p.R304H	DO51953	PRAD	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.25
p.M310I	DO220011	SARC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.0833
p.M310I	DO42033	UCEC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.0833
p.K309I	DO43907	UCEC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	0.1111
p.R294K	SIDM01005	Acute Myeloid Leukemia	GDSC	LREGLGSLH	DEG_APCC_DBOX_1	0.7237
p.R294K	ACH-000263	Leukemia	CCLE	LREGLGSLH	DEG_APCC_DBOX_1	0.7237
p.R294K	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	LREGLGSLH	DEG_APCC_DBOX_1	0.7237
p.L297V	SIDM01689	B-Lymphoblastic Leukemia	GDSC	LREGLGSLH	DEG_APCC_DBOX_1	0.6765
p.T302I	ACH-001521	Skin Cancer	CCLE	LREGLGSLH	DEG_APCC_DBOX_1	0.3056
p.E292K	WM793B	skin	COSMIC	LREGLGSLH	DEG_APCC_DBOX_1	0.3056
p.R300K	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	LREGLGSLH	DEG_APCC_DBOX_1	0.7237

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LREGLGSLH

Degron related mutations and impact score

Drug responses associated with CSF2RB mutations

All proteins holding degron of LREGLGSLH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32927	Cytokine receptor common subunit beta	DEG_APCC_DBOX_1	293:301	LREGLGSLH	APC,CDC20,FZR1	0.7577	More...