DegronMD - P32927(CSF2RB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G298S	TCGA-12-0619	GBM	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.5882
p.G298S	TCGA-12-0692	GBM	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.5882
p.G298S	DO12898	GBM	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.5882
p.G298S	DO14025	GBM	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.5882
p.P311H	TCGA-55-6969	LUAD	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0556
p.H301Q	TCGA-55-8089	LUAD	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.647
p.P569T	TCGA-55-8506	LUAD	TCGA	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.0556
p.S726L	TCGA-AZ-4315	COAD	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7667
p.S726L	DO8842	COAD	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7667
p.S726L	SIDM00534	Colorectal Carcinoma	GDSC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7667
p.S726L	ACH-000986	Colon/Colorectal Cancer	CCLE	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7667
p.S726L	HT-115	large intestine	COSMIC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7667
p.S743I	TCGA-B5-A0JY	UCEC	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.0833
p.L744V	TCGA-BR-8060	STAD	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.0556
p.P311S	TCGA-CZ-4864	KIRC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0556
p.C306R	TCGA-D1-A17M	UCEC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1944
p.C306R	DO43779	UCEC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1944
p.D283N	TCGA-D3-A3C8	SKCM	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0556
p.D283N	DO47636	SKCM	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0556
p.P542H	TCGA-D3-A3CE	SKCM	TCGA	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.0556
p.P542H	DO37405	SKCM	ICGC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.0556
p.G724E	TCGA-D3-A51G	SKCM	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.2778
p.G724E	DO47700	SKCM	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.2778
p.P309L	TCGA-D6-6516	HNSC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1111
p.P309L	DO15623	HNSC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1111
p.G285W	TCGA-DF-A2KU	UCEC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1111
p.D739H	TCGA-DX-A6YQ	SARC	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.1944
p.D739H	DO233777	GACA	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.1944
p.D739H	DO220002	SARC	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.1944
p.P732S	TCGA-EB-A5UN	SKCM	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.6752
p.S729F	TCGA-EE-A20B	SKCM	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.6871
p.S729F	DO37547	SKCM	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.6871
p.G735S	TCGA-EE-A2A5	SKCM	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.3056
p.G735S	SIDM00003	Melanoma	GDSC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.3056
p.G735S	ACH-000884	Skin Cancer	CCLE	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.3056
p.G735S	ACH-002159	Skin Cancer	CCLE	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.3056
p.G735S	M14	skin	COSMIC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.3056
p.H301N	TCGA-EO-A3AV	UCEC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6312
p.H301Y	TCGA-FI-A2D0	UCEC	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6118
p.H301Y	DO43891	UCEC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6118
p.V310M	TCGA-KO-8408	KICH	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0833
p.D716E	TCGA-L9-A5IP	LUAD	TCGA	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.0556
p.D716E	DO49873	LUAD	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.0556
p.P567A	TCGA-OR-A5L2	ACC	TCGA	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.1111
p.E286K	TCGA-RP-A695	SKCM	TCGA	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1389
p.E286K	DO51270	SKCM	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1389
p.E286K	SIDM00973	Melanoma	GDSC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1389
p.E286K	WM793B	skin	COSMIC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1389
p.P718A	DO49904	CESC	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.1111
p.V732F	DO220360	KICH	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7068
p.A288S	DO228936	LICA	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1944
p.P556S	DO229052	LICA	ICGC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation altering degron motif	0.6752
p.E295K	DO222402	MELA	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.591
p.P569S	DO222683	MELA	ICGC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.0556
p.P569H	DO50672	ORCA	ICGC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.0556
p.V732A	DO46657	PAAD	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.6936
p.R304H	DO51953	PRAD	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.25
p.M310I	DO220011	SARC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0833
p.M310I	DO42033	UCEC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.0833
p.N729S	DO47362	SKCM	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7069
p.K309I	DO43907	UCEC	ICGC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.1111
p.P731H	DO42713	UCEC	ICGC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7694
p.R294K	SIDM01005	Acute Myeloid Leukemia	GDSC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.7237
p.R294K	ACH-000263	Leukemia	CCLE	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.7237
p.R294K	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.7237
p.H544R	SIDM00523	Small Cell Lung Carcinoma	GDSC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.1111
p.H544R	ACH-000698	Lung Cancer	CCLE	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.1111
p.H544R	DMS-53	lung	COSMIC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.1111
p.P552T	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation altering degron motif	0.7031
p.P552T	ACH-000744	Lung Cancer	CCLE	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation altering degron motif	0.7031
p.P552T	NCI-H1623	lung	COSMIC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation altering degron motif	0.7031
p.L297V	SIDM01689	B-Lymphoblastic Leukemia	GDSC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.6765
p.S550F	ACH-000868	Lung Cancer	CCLE	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.2778
p.T302I	ACH-001521	Skin Cancer	CCLE	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.3056
p.A721S	KM-H2	haematopoietic and lymphoid tissue	COSMIC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.1944
p.E292K	WM793B	skin	COSMIC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation rewiring degron network	0.3056
p.R300K	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	LREGLGSLH	DEG_APCC_DBOX_1	293:301	Mutation altering degron motif	0.7237
p.S732L	HT-115	large intestine	COSMIC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation altering degron motif	0.7667
p.P558T	NCI-H1623	lung	COSMIC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation altering degron motif	0.7031
p.G741S	M14	skin	COSMIC	SSVSLVPSL	DEG_COP1_1	726:734	Mutation rewiring degron network	0.1389
p.H550R	DMS-53	lung	COSMIC	PDTTPAAS	DEG_SCF_FBW7_1	552:559	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSF2RB

UniProt ID: P32927

Entrez ID: 1439

Protein name: Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSF2RB in