DegronMD

Uniprot ID: P32927

Source protein: Cytokine receptor common subunit beta

Source gene: CSF2RB

Class: DEG_COP1_1

Location: 726:734

E3 ligase: COP1

DEGRON score: 0.9778

ASA_SCORE: 73.9

COIL: 0.9093

CONS_SCORE: 0.2742

DSS_SCORE: 0.4214

HELIX: 0.0441

FCONS_SCORE: 0.7586

RIG_SCORE: 0.7076

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S726L	TCGA-AZ-4315	COAD	TCGA	SSVSLVPSL	DEG_COP1_1	0.7667
p.S726L	DO8842	COAD	ICGC	SSVSLVPSL	DEG_COP1_1	0.7667
p.S726L	SIDM00534	Colorectal Carcinoma	GDSC	SSVSLVPSL	DEG_COP1_1	0.7667
p.S726L	ACH-000986	Colon/Colorectal Cancer	CCLE	SSVSLVPSL	DEG_COP1_1	0.7667
p.S726L	HT-115	large_intestine	COSMIC	SSVSLVPSL	DEG_COP1_1	0.7667
p.S743I	TCGA-B5-A0JY	UCEC	TCGA	SSVSLVPSL	DEG_COP1_1	0.0833
p.L744V	TCGA-BR-8060	STAD	TCGA	SSVSLVPSL	DEG_COP1_1	0.0556
p.G724E	TCGA-D3-A51G	SKCM	TCGA	SSVSLVPSL	DEG_COP1_1	0.2778
p.G724E	DO47700	SKCM	ICGC	SSVSLVPSL	DEG_COP1_1	0.2778
p.D739H	TCGA-DX-A6YQ	SARC	TCGA	SSVSLVPSL	DEG_COP1_1	0.1944
p.D739H	DO233777	GACA	ICGC	SSVSLVPSL	DEG_COP1_1	0.1944
p.D739H	DO220002	SARC	ICGC	SSVSLVPSL	DEG_COP1_1	0.1944
p.P732S	TCGA-EB-A5UN	SKCM	TCGA	SSVSLVPSL	DEG_COP1_1	0.6752
p.S729F	TCGA-EE-A20B	SKCM	TCGA	SSVSLVPSL	DEG_COP1_1	0.6871
p.S729F	DO37547	SKCM	ICGC	SSVSLVPSL	DEG_COP1_1	0.6871
p.G735S	TCGA-EE-A2A5	SKCM	TCGA	SSVSLVPSL	DEG_COP1_1	0.3056
p.G735S	SIDM00003	Melanoma	GDSC	SSVSLVPSL	DEG_COP1_1	0.3056
p.G735S	ACH-000884	Skin Cancer	CCLE	SSVSLVPSL	DEG_COP1_1	0.3056
p.G735S	ACH-002159	Skin Cancer	CCLE	SSVSLVPSL	DEG_COP1_1	0.3056
p.G735S	M14	skin	COSMIC	SSVSLVPSL	DEG_COP1_1	0.3056
p.D716E	TCGA-L9-A5IP	LUAD	TCGA	SSVSLVPSL	DEG_COP1_1	0.0556
p.D716E	DO49873	LUAD	ICGC	SSVSLVPSL	DEG_COP1_1	0.0556
p.P718A	DO49904	CESC	ICGC	SSVSLVPSL	DEG_COP1_1	0.1111
p.V732F	DO220360	KICH	ICGC	SSVSLVPSL	DEG_COP1_1	0.7068
p.V732A	DO46657	PAAD	ICGC	SSVSLVPSL	DEG_COP1_1	0.6936
p.N729S	DO47362	SKCM	ICGC	SSVSLVPSL	DEG_COP1_1	0.7069
p.P731H	DO42713	UCEC	ICGC	SSVSLVPSL	DEG_COP1_1	0.7694
p.A721S	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	SSVSLVPSL	DEG_COP1_1	0.1944
p.S732L	HT-115	large_intestine	COSMIC	SSVSLVPSL	DEG_COP1_1	0.7667
p.G741S	M14	skin	COSMIC	SSVSLVPSL	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSVSLVPSL

Degron related mutations and impact score

Drug responses associated with CSF2RB mutations

All proteins holding degron of SSVSLVPSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32927	Cytokine receptor common subunit beta	DEG_COP1_1	726:734	SSVSLVPSL	COP1	0.9778	More...