DegronMD

Uniprot ID: P32927

Source protein: Cytokine receptor common subunit beta

Source gene: CSF2RB

Class: DEG_SCF_FBW7_1

Location: 552:559

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 76.225

COIL: 0.8223

CONS_SCORE: 0.4143

DSS_SCORE: 0.858

HELIX: 0.133

FCONS_SCORE: 1.3393

RIG_SCORE: 0.5567

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P569T	TCGA-55-8506	LUAD	TCGA	PDTTPAAS	DEG_SCF_FBW7_1	0.0556
p.P542H	TCGA-D3-A3CE	SKCM	TCGA	PDTTPAAS	DEG_SCF_FBW7_1	0.0556
p.P542H	DO37405	SKCM	ICGC	PDTTPAAS	DEG_SCF_FBW7_1	0.0556
p.P567A	TCGA-OR-A5L2	ACC	TCGA	PDTTPAAS	DEG_SCF_FBW7_1	0.1111
p.P556S	DO229052	LICA	ICGC	PDTTPAAS	DEG_SCF_FBW7_1	0.6752
p.P569S	DO222683	MELA	ICGC	PDTTPAAS	DEG_SCF_FBW7_1	0.0556
p.P569H	DO50672	ORCA	ICGC	PDTTPAAS	DEG_SCF_FBW7_1	0.0556
p.H544R	SIDM00523	Small Cell Lung Carcinoma	GDSC	PDTTPAAS	DEG_SCF_FBW7_1	0.1111
p.H544R	ACH-000698	Lung Cancer	CCLE	PDTTPAAS	DEG_SCF_FBW7_1	0.1111
p.H544R	DMS-53	lung	COSMIC	PDTTPAAS	DEG_SCF_FBW7_1	0.1111
p.P552T	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PDTTPAAS	DEG_SCF_FBW7_1	0.7031
p.P552T	ACH-000744	Lung Cancer	CCLE	PDTTPAAS	DEG_SCF_FBW7_1	0.7031
p.P552T	NCI-H1623	lung	COSMIC	PDTTPAAS	DEG_SCF_FBW7_1	0.7031
p.S550F	ACH-000868	Lung Cancer	CCLE	PDTTPAAS	DEG_SCF_FBW7_1	0.2778
p.P558T	NCI-H1623	lung	COSMIC	PDTTPAAS	DEG_SCF_FBW7_1	0.7031
p.H550R	DMS-53	lung	COSMIC	PDTTPAAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32927	Cytokine receptor common subunit beta	DEG_SCF_FBW7_1	552:559	PDTTPAAS	FBXW7	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons