DegronMD

Uniprot ID: H7BZ55

Source protein: Ciliary rootlet coiled-coil protein 2

Source gene: CROCC2

Class: DEG_APCC_DBOX_1

Location: 174:182

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8666

ASA_SCORE: 110.8444

COIL: 0.026

CONS_SCORE: 0.4924

DSS_SCORE: 0.3086

HELIX: 0.9757

FCONS_SCORE: 1.2415

RIG_SCORE: 0.8083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A184T	SIDM00845	Burkitt's Lymphoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.2778
p.G166S	SIDM00919	Ovarian Carcinoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.1111
p.G166S	SIDM00203	Ewing's Sarcoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.1111
p.G166S	SIDM00254	Neuroblastoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.1111
p.G166S	SIDM00672	Hepatocellular Carcinoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.1111
p.G166S	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.1111
p.G166S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.1111
p.G166S	SIDM00261	Ewing's Sarcoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.1111
p.G166S	SIDM00628	Breast Carcinoma	GDSC	LREQLEHMK	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
H7BZ55	Ciliary rootlet coiled-coil protein 2	DEG_APCC_DBOX_1	174:182	LREQLEHMK	APC,CDC20,FZR1	0.8666	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons