DegronMD

Uniprot ID: Q5U5Q3

Source protein: RNA-binding E3 ubiquitin-protein ligase MEX3C

Source gene: MEX3C

Class: DEG_APCC_DBOX_1

Location: 48:56

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9819

ASA_SCORE: 68.5444

COIL: 0.2389

CONS_SCORE: 0.3724

DSS_SCORE: 0.6666

HELIX: 0.7532

FCONS_SCORE: 1.4435

RIG_SCORE: 0.7555

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N44D	DO233888	GACA	ICGC	LRERLAALG	DEG_APCC_DBOX_1	0.2222
p.K41N	DO50006	HNSC	ICGC	LRERLAALG	DEG_APCC_DBOX_1	0.1389
p.R63L	DO228827	LICA	ICGC	LRERLAALG	DEG_APCC_DBOX_1	0.1389
p.K41E	DO229213	THCA	ICGC	LRERLAALG	DEG_APCC_DBOX_1	0.1389
p.H56Q	ACH-000549	Head and Neck Cancer	CCLE	LRERLAALG	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5U5Q3	RNA-binding E3 ubiquitin-protein ligase MEX3C	DEG_APCC_DBOX_1	48:56	LRERLAALG	APC,CDC20,FZR1	0.9819	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons