DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LRFPLSHLD
Uniprot ID:
Q8IUF8
Source protein:
Ribosomal oxygenase 2
Source gene:
RIOX2
Class:
DEG_APCC_DBOX_1
Location:
417:425
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5189
ASA_SCORE:
48.4556
COIL:
0.1727
CONS_SCORE:
0.5066
DSS_SCORE:
0.2239
HELIX:
0.4902
FCONS_SCORE:
1.2284
RIG_SCORE:
0.794
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RIOX2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRFPLSHLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IUF8
Ribosomal oxygenase 2
DEG_APCC_DBOX_1
417:425
LRFPLSHLD
APC,CDC20,FZR1
0.5189
More...