DegronMD

Uniprot ID: Q9ULG6

Source protein: Cell cycle progression protein 1

Source gene: CCPG1

Class: DEG_APCC_DBOX_1

Location: 396:404

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5284

ASA_SCORE: 88.8222

COIL: 0.2728

CONS_SCORE: 0.5396

DSS_SCORE: 0.4432

HELIX: 0.7229

FCONS_SCORE: 1.1322

RIG_SCORE: 0.7329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E399G	TCGA-BS-A0UV	UCEC	TCGA	LRGELQQLS	DEG_APCC_DBOX_1	0.6087
p.E399G	DO42793	UCEC	ICGC	LRGELQQLS	DEG_APCC_DBOX_1	0.6087
p.A395S	TCGA-DS-A0VM	CESC	TCGA	LRGELQQLS	DEG_APCC_DBOX_1	0.3056
p.A395S	DO6258	CESC	ICGC	LRGELQQLS	DEG_APCC_DBOX_1	0.3056
p.A395D	DO228952	LICA	ICGC	LRGELQQLS	DEG_APCC_DBOX_1	0.3056
p.R397S	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	LRGELQQLS	DEG_APCC_DBOX_1	0.7427
p.R397S	ACH-000664	Lymphoma	CCLE	LRGELQQLS	DEG_APCC_DBOX_1	0.7427
p.R397S	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRGELQQLS	DEG_APCC_DBOX_1	0.7427
p.G398V	SIDM00789	Colorectal Carcinoma	GDSC	LRGELQQLS	DEG_APCC_DBOX_1	0.6421
p.G398V	ACH-000997	Colon/Colorectal Cancer	CCLE	LRGELQQLS	DEG_APCC_DBOX_1	0.6421
p.G398V	ACH-001061	Colon/Colorectal Cancer	CCLE	LRGELQQLS	DEG_APCC_DBOX_1	0.6421
p.G398V	HCT-15	large_intestine	COSMIC	LRGELQQLS	DEG_APCC_DBOX_1	0.6421
p.H409R	SIDM00043	Head and Neck Carcinoma	GDSC	LRGELQQLS	DEG_APCC_DBOX_1	0.1944
p.H409R	ACH-002297	Head and Neck Cancer	CCLE	LRGELQQLS	DEG_APCC_DBOX_1	0.1944
p.H409R	PCI-4B	upper_aerodigestive_tract	COSMIC	LRGELQQLS	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULG6	Cell cycle progression protein 1	DEG_APCC_DBOX_1	396:404	LRGELQQLS	APC,CDC20,FZR1	0.5284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons