DegronMD

Uniprot ID: Q86W92

Source protein: Liprin-beta-1

Source gene: PPFIBP1

Class: DEG_APCC_DBOX_1

Location: 55:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7822

ASA_SCORE: 68.9

COIL: 0.1919

CONS_SCORE: 0.6579

DSS_SCORE: 0.3316

HELIX: 0.8036

FCONS_SCORE: 1.0338

RIG_SCORE: 0.8002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V52L	TCGA-44-7670	LUAD	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	0.25
p.V52L	DO23555	LUAD	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.25
p.R56C	TCGA-AP-A1DR	UCEC	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	0.8301
p.R56C	DO43747	UCEC	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.8301
p.R56L	TCGA-B0-5117	KIRC	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	0.8428
p.R56L	DO17987	KIRC	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.8428
p.R56L	DO228985	LICA	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.8428
p.A48D	TCGA-EI-7002	READ	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	0.1389
p.A48D	DO36598	READ	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.1389
p.L70M	TCGA-FD-A3SJ	BLCA	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	0.1389
p.L70M	DO681	BLCA	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.1389
p.D65Y	TCGA-FI-A2D5	UCEC	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	0.2778
p.D65Y	DO41331	UCEC	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.2778
p.E68D	TCGA-G3-A7M9	LIHC	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	0.1944
p.E68D	DO49694	LIHC	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.1944
p.R56H	DO234295	ESAD	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.8244
p.R56H	SIDM00217	Colorectal Carcinoma	GDSC	LRGLLEMME	DEG_APCC_DBOX_1	0.8244
p.R56H	ACH-000999	Colon/Colorectal Cancer	CCLE	LRGLLEMME	DEG_APCC_DBOX_1	0.8244
p.R56H	SNU-1040	large_intestine	COSMIC	LRGLLEMME	DEG_APCC_DBOX_1	0.8244
p.L49V	DO234133	THCA	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	0.1667
p.D54Y	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	LRGLLEMME	DEG_APCC_DBOX_1	0.3056
p.D54Y	ACH-000912	Lung Cancer	CCLE	LRGLLEMME	DEG_APCC_DBOX_1	0.3056
p.E48K	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LRGLLEMME	DEG_APCC_DBOX_1	0.1389
p.R58S	HTC-C3	thyroid	COSMIC	LRGLLEMME	DEG_APCC_DBOX_1	0.7427
p.D65G	MKN1	stomach	COSMIC	LRGLLEMME	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86W92	Liprin-beta-1	DEG_APCC_DBOX_1	55:63	LRGLLEMME	APC,CDC20,FZR1	0.7822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRGLLEMME

Degron related mutations and impact score

Drug responses associated with PPFIBP1 mutations

All proteins holding degron of LRGLLEMME