DegronMD - Q86W92(PPFIBP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V52L	TCGA-44-7670	LUAD	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.V52L	DO23555	LUAD	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.R56C	TCGA-AP-A1DR	UCEC	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8301
p.R56C	DO43747	UCEC	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8301
p.R958W	TCGA-AX-A06H	UCEC	TCGA	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1944
p.R56L	TCGA-B0-5117	KIRC	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8428
p.R56L	DO17987	KIRC	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8428
p.R56L	DO228985	LICA	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8428
p.D947N	TCGA-DF-A2KU	UCEC	TCGA	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.3056
p.A48D	TCGA-EI-7002	READ	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.A48D	DO36598	READ	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.L70M	TCGA-FD-A3SJ	BLCA	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.L70M	DO681	BLCA	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.D65Y	TCGA-FI-A2D5	UCEC	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.D65Y	DO41331	UCEC	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.E68D	TCGA-G3-A7M9	LIHC	TCGA	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1944
p.E68D	DO49694	LIHC	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1944
p.V431I	DO225337	BRCA	ICGC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation altering degron motif	0.7076
p.R943H	DO228483	BRCA	ICGC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation blocking ubiquitination signal	0.6389
p.R943H	DO229010	COCA	ICGC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation blocking ubiquitination signal	0.6389
p.R952Q	DO227709	COCA	ICGC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7329
p.R952Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7329
p.R952Q	JM1	haematopoietic and lymphoid tissue	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7329
p.R952Q	SNU-407	large intestine	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7329
p.D437G	DO229013	COCA	ICGC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.1944
p.R56H	DO234295	ESAD	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8244
p.R56H	SIDM00217	Colorectal Carcinoma	GDSC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8244
p.R56H	ACH-000999	Colon/Colorectal Cancer	CCLE	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8244
p.R56H	SNU-1040	large intestine	COSMIC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.8244
p.G423E	DO233691	GACA	ICGC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.2222
p.E960K	DO44440	HNSC	ICGC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1389
p.L940F	DO229032	LICA	ICGC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation blocking ubiquitination signal	0.5556
p.E419K	DO27943	ORCA	ICGC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.1111
p.G428C	DO47623	SKCM	ICGC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation altering degron motif	0.76
p.L49V	DO234133	THCA	ICGC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1667
p.R952W	DO43530	UCEC	ICGC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.8634
p.R952W	ACH-001329	Brain Cancer	CCLE	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.8634
p.D941N	DO223286	UCEC	ICGC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1389
p.V417I	SIDM02061	Esophageal Carcinoma	GDSC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.0556
p.R949C	SIDM01307	Colorectal Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.719
p.R949C	SIDM00534	Colorectal Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.719
p.R949C	ACH-000170	Non-Cancerous	CCLE	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.719
p.R949C	HT-115	large intestine	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.719
p.R949H	SIDM00570	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00450	Acute Myeloid Leukemia	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00586	Hepatocellular Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01151	Hepatocellular Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00377	Other Sarcomas	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00584	Osteosarcoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00496	Thyroid Gland Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00281	Other Solid Cancers	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00573	Glioblastoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01148	Plasma Cell Myeloma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00562	Breast Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00383	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00587	Biliary Tract Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01180	Hepatocellular Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00410	Other Blood Cancers	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00612	Glioma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01653	Non-Cancerous	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00907	Burkitt's Lymphoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00207	Glioblastoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00807	Bladder Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00469	Pancreatic Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00279	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00192	Colorectal Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01449	Pancreatic Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01682	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01617	Endometrial Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01470	Acute Myeloid Leukemia	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01526	Mesothelioma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00167	Head and Neck Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00169	Head and Neck Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01445	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01447	Glioblastoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01448	Head and Neck Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01473	Plasma Cell Myeloma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01574	Plasma Cell Myeloma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM00159	Biliary Tract Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R949H	SIDM01619	Endometrial Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation altering degron motif	0.7133
p.R958Q	SIDM00689	B-Lymphoblastic Leukemia	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1944
p.R958Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1944
p.R958Q	SIDM00214	Colorectal Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1944
p.R958Q	JM1	haematopoietic and lymphoid tissue	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1944
p.R958Q	SNU-407	large intestine	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1944
p.R958Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1944
p.S425P	SIDM01463	Endometrial Carcinoma	GDSC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.2778
p.D54Y	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.3056
p.D54Y	ACH-000912	Lung Cancer	CCLE	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.3056
p.M419V	SIDM00170	Head and Neck Carcinoma	GDSC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.1111
p.R943C	ACH-000986	Colon/Colorectal Cancer	CCLE	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation blocking ubiquitination signal	0.6389
p.R943C	HT-115	large intestine	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation blocking ubiquitination signal	0.6389
p.A429T	ACH-002163	Breast Cancer	CCLE	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation altering degron motif	0.7139
p.A429T	MRK-nu-1	breast	COSMIC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation altering degron motif	0.7139
p.E48K	PF-382	haematopoietic and lymphoid tissue	COSMIC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.K431Q	MSTO-211H	pleura	COSMIC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation altering degron motif	0.6944
p.I941M	LNCaP-Clone-FGC	prostate	COSMIC	MRLYEE	LIG_APCC_ABBA_1	948:953	Mutation rewiring degron network	0.1389
p.L439P	SW1573	lung	COSMIC	LTPKPE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.1389
p.R58S	HTC-C3	thyroid	COSMIC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7427
p.D65G	MKN1	stomach	COSMIC	LRGLLEMME	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPFIBP1

UniProt ID: Q86W92

Entrez ID: 8496

Protein name: Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPFIBP1 in