DegronMD

Uniprot ID: Q86W92

Source protein: Liprin-beta-1

Source gene: PPFIBP1

Class: LIG_APCC_ABBA_1

Location: 948:953

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8288

ASA_SCORE: 102

COIL: 0.69

CONS_SCORE: 0.3747

DSS_SCORE: 0.4666

HELIX: 0.2052

FCONS_SCORE: 0.8387

RIG_SCORE: 0.8101

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R958W	TCGA-AX-A06H	UCEC	TCGA	MRLYEE	LIG_APCC_ABBA_1	0.1944
p.D947N	TCGA-DF-A2KU	UCEC	TCGA	MRLYEE	LIG_APCC_ABBA_1	0.3056
p.R943H	DO228483	BRCA	ICGC	MRLYEE	LIG_APCC_ABBA_1	0.6389
p.R943H	DO229010	COCA	ICGC	MRLYEE	LIG_APCC_ABBA_1	0.6389
p.R952Q	DO227709	COCA	ICGC	MRLYEE	LIG_APCC_ABBA_1	0.7329
p.R952Q	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.7329
p.R952Q	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.7329
p.R952Q	SNU-407	large_intestine	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.7329
p.E960K	DO44440	HNSC	ICGC	MRLYEE	LIG_APCC_ABBA_1	0.1389
p.L940F	DO229032	LICA	ICGC	MRLYEE	LIG_APCC_ABBA_1	0.5556
p.R952W	DO43530	UCEC	ICGC	MRLYEE	LIG_APCC_ABBA_1	0.8634
p.R952W	ACH-001329	Brain Cancer	CCLE	MRLYEE	LIG_APCC_ABBA_1	0.8634
p.D941N	DO223286	UCEC	ICGC	MRLYEE	LIG_APCC_ABBA_1	0.1389
p.R949C	SIDM01307	Colorectal Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.719
p.R949C	SIDM00534	Colorectal Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.719
p.R949C	ACH-000170	Non-Cancerous	CCLE	MRLYEE	LIG_APCC_ABBA_1	0.719
p.R949C	HT-115	large_intestine	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.719
p.R949H	SIDM00570	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00450	Acute Myeloid Leukemia	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00586	Hepatocellular Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01151	Hepatocellular Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00377	Other Sarcomas	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00584	Osteosarcoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00496	Thyroid Gland Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00281	Other Solid Cancers	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00573	Glioblastoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01148	Plasma Cell Myeloma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00562	Breast Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00383	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00587	Biliary Tract Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01180	Hepatocellular Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00410	Other Blood Cancers	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00612	Glioma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01653	Non-Cancerous	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00907	Burkitt's Lymphoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00207	Glioblastoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00807	Bladder Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00469	Pancreatic Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00279	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00192	Colorectal Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01449	Pancreatic Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01682	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01617	Endometrial Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01470	Acute Myeloid Leukemia	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01526	Mesothelioma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00167	Head and Neck Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00169	Head and Neck Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01445	Gastric Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01447	Glioblastoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01448	Head and Neck Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01473	Plasma Cell Myeloma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01574	Plasma Cell Myeloma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM00159	Biliary Tract Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R949H	SIDM01619	Endometrial Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.7133
p.R958Q	SIDM00689	B-Lymphoblastic Leukemia	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.1944
p.R958Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.1944
p.R958Q	SIDM00214	Colorectal Carcinoma	GDSC	MRLYEE	LIG_APCC_ABBA_1	0.1944
p.R958Q	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.1944
p.R958Q	SNU-407	large_intestine	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.1944
p.R958Q	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.1944
p.R943C	ACH-000986	Colon/Colorectal Cancer	CCLE	MRLYEE	LIG_APCC_ABBA_1	0.6389
p.R943C	HT-115	large_intestine	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.6389
p.I941M	LNCaP-Clone-FGC	prostate	COSMIC	MRLYEE	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MRLYEE

Degron related mutations and impact score

Drug responses associated with PPFIBP1 mutations

All proteins holding degron of MRLYEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86W92	Liprin-beta-1	LIG_APCC_ABBA_1	948:953	MRLYEE	APC,CDC20,FZR1	0.8288	More...