DegronMD

Uniprot ID: Q86W92

Source protein: Liprin-beta-1

Source gene: PPFIBP1

Class: DEG_SCF_FBW7_2

Location: 427:432

E3 ligase: FBXW7

DEGRON score: 0.989

ASA_SCORE: 106.4667

COIL: 0.9417

CONS_SCORE: 0.3999

DSS_SCORE: 0.6459

HELIX: 0.0323

FCONS_SCORE: 1.1501

RIG_SCORE: 0.6779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V431I	DO225337	BRCA	ICGC	LTPKPE	DEG_SCF_FBW7_2	0.7076
p.D437G	DO229013	COCA	ICGC	LTPKPE	DEG_SCF_FBW7_2	0.1944
p.G423E	DO233691	GACA	ICGC	LTPKPE	DEG_SCF_FBW7_2	0.2222
p.E419K	DO27943	ORCA	ICGC	LTPKPE	DEG_SCF_FBW7_2	0.1111
p.G428C	DO47623	SKCM	ICGC	LTPKPE	DEG_SCF_FBW7_2	0.76
p.V417I	SIDM02061	Esophageal Carcinoma	GDSC	LTPKPE	DEG_SCF_FBW7_2	0.0556
p.S425P	SIDM01463	Endometrial Carcinoma	GDSC	LTPKPE	DEG_SCF_FBW7_2	0.2778
p.M419V	SIDM00170	Head and Neck Carcinoma	GDSC	LTPKPE	DEG_SCF_FBW7_2	0.1111
p.A429T	ACH-002163	Breast Cancer	CCLE	LTPKPE	DEG_SCF_FBW7_2	0.7139
p.A429T	MRK-nu-1	breast	COSMIC	LTPKPE	DEG_SCF_FBW7_2	0.7139
p.K431Q	MSTO-211H	pleura	COSMIC	LTPKPE	DEG_SCF_FBW7_2	0.6944
p.L439P	SW1573	lung	COSMIC	LTPKPE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86W92	Liprin-beta-1	DEG_SCF_FBW7_2	427:432	LTPKPE	FBXW7	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons