DegronMD

Uniprot ID: A6NC98

Source protein: Coiled-coil domain-containing protein 88B

Source gene: CCDC88B

Class: DEG_APCC_DBOX_1

Location: 471:479

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5518

ASA_SCORE: 86.1222

COIL: 0.0878

CONS_SCORE: 0.5057

DSS_SCORE: 0.5277

HELIX: 0.9151

FCONS_SCORE: 1.3251

RIG_SCORE: 0.7453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E467D	TCGA-EO-A22U	UCEC	TCGA	LRGLLQVLQ	DEG_APCC_DBOX_1	0.2222
p.E467D	DO43755	UCEC	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.2222
p.E470K	TCGA-EO-A22U	UCEC	TCGA	LRGLLQVLQ	DEG_APCC_DBOX_1	0.3056
p.E470K	DO43755	UCEC	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.3056
p.V477L	DO229015	LICA	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.5654
p.G489V	DO229025	LICA	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.0556
p.R472L	DO229026	LICA	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.8428
p.G484S	DO23316	LINC	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.1944
p.R469Q	DO231102	LUSC	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.2778
p.R469Q	SIDM00570	Gastric Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.2778
p.R469Q	SIDM01511	Gastric Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.2778
p.P485L	DO51268	SKCM	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.1667
p.P482T	SIDM00871	Non-Cancerous	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.25
p.G483W	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.2222
p.G483W	ACH-000945	Lung Cancer	CCLE	LRGLLQVLQ	DEG_APCC_DBOX_1	0.2222
p.R472W	SIDM00420	Bladder Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.8634
p.G484D	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.1944
p.G484D	SIDM01611	Endometrial Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.1944
p.G484D	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.1944
p.R462Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	0.0833
p.R462Q	ACH-002222	Leukemia	CCLE	LRGLLQVLQ	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NC98	Coiled-coil domain-containing protein 88B	DEG_APCC_DBOX_1	471:479	LRGLLQVLQ	APC,CDC20,FZR1	0.5518	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons